Global Patent Index - EP 1255533 A2

EP 1255533 A2 2002-11-13 - MAGNETOLIPOSOME COMPOSITION FOR TARGETED TREATMENT OF BIOLOGICAL TISSUE

Title (en)

MAGNETOLIPOSOME COMPOSITION FOR TARGETED TREATMENT OF BIOLOGICAL TISSUE

Title (de)

ZUBEREITUNG ENTHALTEND MAGNETOLIPOSOMEN ZUR GEZIELTEN BEHANDLUNG VON BIOLOGISCHEM GEWEBE

Title (fr)

COMPOSITION A BASE DE MAGNETOLIPOSOMES, DESTINEE AU TRAITEMENT CIBLE D'UN TISSU BIOLOGIQUE

Publication

EP 1255533 A2 (EN)

Application

EP 01906995 A

Priority

  • US 0103738 W
  • US 18049400 P

Abstract (en)

[origin: WO0156546A2] A composition for treatment of biological tissue responsive to an applied magnetic field comprises a plurality of magnetoliposomes, each magnetoliposome of the plurality having a lipid-containing wall defining a vesicle, and a plurality of subdomain superparamagnetic particles, and an inactive prodrug capable of activating into a drug effective for treatment of the biological tissue, the prodrug carried by the plurality of magnetoliposomes for delivery to the biological tissue. A method of treatment for a biological tissue comprises administering the composition to the tissue, concentrating the plurality of magnetoliposomes in the biological tissue responsive to a substantially constant magnetic field, activating the inactive prodrug into an effective drug by applying an electromagnetic field to the concentrated plurality of magnetoliposomes so as to therein generate heat sufficient for activation without appreciable rupture of individual magnetoliposomes of the plurality of magnetoliposomes, and releasing the activated effective drug into the biological tissue by sufficiently increasing permeability of the lipid-containing walls of individual magnetoliposomes of the plurality of magnetoliposomes to thereby release activated drug.

IPC 1-7 (main, further and additional classification)

A61K 9/127; A61K 9/00; A61K 41/00

IPC 8 full level (invention and additional information)

A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 41/00 (2006.01)

CPC (invention and additional information)

A61K 41/0052 (2013.01); A61K 9/0009 (2013.01); A61K 9/127 (2013.01)

Citation (search report)

See references of WO 0156546A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0156546 A2 20010809; WO 0156546 A3 20020131; AU 3483101 A 20010814; EP 1255533 A2 20021113

INPADOC legal status


2005-01-19 [18W] APPLICATION WITHDRAWN

- Effective date: 20041201

2002-11-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020904

2002-11-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020904;LT PAYMENT 20020904;LV PAYMENT 20020904;MK PAYMENT 20020904;RO PAYMENT 20020904;SI PAYMENT 20020904