EP 1255568 A2 20021113 - CONJUGATES TARGETED TO TARGET RECEPTORS
Title (en)
CONJUGATES TARGETED TO TARGET RECEPTORS
Title (de)
AN ZIELREZEPTORE GEZIELTE KONJUGATE
Title (fr)
CONJUGUES CIBLES SUR DES RECEPTEURS CIBLES
Publication
Application
Priority
- US 0105225 W 20010215
- US 50714000 A 20000218
Abstract (en)
[origin: WO0160848A2] A conjugate for intracellular delivery of a chemical agent into a target receptor such as an interleukin-2-receptor-bearing cell, <i>e.g.</i>, an activated T cell and cancer cell, includes a chemical agent, at least one copy of target-receptor binding and endocytosis-inducing ligand coupled to a water soluble polymer. The ligand binds to a target receptor such as an IL-2 receptor on the target receptor bearing cell and elicits endocytosis of the conjugate. The conjugate also optionally includes a biodegradable spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyalkylene oxide, such as polyethylene glycol and polyethylene oxide, and activated derivatives thereof. Methods of using these compositions for delivering a chemical agent <i>in vivo</i>or <i>in vitro</i> are also disclosed. Methods of detecting a disease, such as cancer, T-cell lymphocytic leukemia, T-cell acute lymphoblastic leukemia, peripheral T-cell lymphoma, Hodgkin's disease, and non-Hodgkin's lymphoma, associated with elevated levels of soluble target receptor and/or IL-2 receptor also are disclosed.
IPC 1-7
IPC 8 full level
A61K 47/48 (2006.01); C07K 5/103 (2006.01); C07K 14/55 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 47/6425 (2017.07); C07K 5/1008 (2013.01); C07K 14/55 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0160848A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0160848 A2 20010823; WO 0160848 A3 20020425; AU 4154901 A 20010827; CA 2398395 A1 20010823; EP 1255568 A2 20021113
DOCDB simple family (application)
US 0105225 W 20010215; AU 4154901 A 20010215; CA 2398395 A 20010215; EP 01912804 A 20010215