Global Patent Index - EP 1255568 A2

EP 1255568 A2 2002-11-13 - CONJUGATES TARGETED TO TARGET RECEPTORS

Title (en)

CONJUGATES TARGETED TO TARGET RECEPTORS

Title (de)

AN ZIELREZEPTORE GEZIELTE KONJUGATE

Title (fr)

CONJUGUES CIBLES SUR DES RECEPTEURS CIBLES

Publication

EP 1255568 A2 (EN)

Application

EP 01912804 A

Priority

  • US 0105225 W
  • US 50714000 A

Abstract (en)

[origin: WO0160848A2] A conjugate for intracellular delivery of a chemical agent into a target receptor such as an interleukin-2-receptor-bearing cell, <i>e.g.</i>, an activated T cell and cancer cell, includes a chemical agent, at least one copy of target-receptor binding and endocytosis-inducing ligand coupled to a water soluble polymer. The ligand binds to a target receptor such as an IL-2 receptor on the target receptor bearing cell and elicits endocytosis of the conjugate. The conjugate also optionally includes a biodegradable spacer for coupling the chemical agent and the ligand to the polymer. Chemical agents can include cytotoxins, transforming nucleic acids, gene regulators, labels, antigens, drugs, and the like. A preferred water soluble polymer is polyalkylene oxide, such as polyethylene glycol and polyethylene oxide, and activated derivatives thereof. Methods of using these compositions for delivering a chemical agent <i>in vivo</i>or <i>in vitro</i> are also disclosed. Methods of detecting a disease, such as cancer, T-cell lymphocytic leukemia, T-cell acute lymphoblastic leukemia, peripheral T-cell lymphoma, Hodgkin's disease, and non-Hodgkin's lymphoma, associated with elevated levels of soluble target receptor and/or IL-2 receptor also are disclosed.

IPC 1-7 (main, further and additional classification)

A61K 47/48; A61K 38/04; C07K 5/10; C07K 14/55; G01N 33/68

IPC 8 full level (invention and additional information)

A61K 47/48 (2006.01); C07K 5/103 (2006.01); C07K 14/55 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 5/1008 (2013.01); A61K 47/6425 (2017.08); C07K 14/55 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 0160848A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0160848 A2 20010823; WO 0160848 A3 20020425; AU 4154901 A 20010827; CA 2398395 A1 20010823; EP 1255568 A2 20021113

INPADOC legal status


2005-08-31 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20050202

2004-01-21 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20031208

2002-11-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020905

2002-11-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI