EP 1255758 A1 20021113 - APOPTOSIS-INDUCING COMPOUNDS

Title (en)

APOPTOSIS-INDUCING COMPOUNDS

Title (de)

APOPTOSE-INDUZIERENDE VERBINDUNGEN

Title (fr)

COMPOSES INDUISANT L'APOPTOSE

Publication

EP 1255758 A1 20021113 (EN)

Application

EP 01904273 A 20010209

Priority

IE 0100020 W 20010209
IE 20000120 A 20000211

Abstract (en)

[origin: WO0158904A1] The invention relates to a pharmaceutical composition comprising an apoptosis-inducing amount of a compound having general formula (I), wherein: (i) R1 represents an unsubstituted C6 or C10 aryl group; or a C6 aryl group substituted with Me or OMe; (ii) A represents O, S or S partially oxidized to sulfoxide; (iii) the cyclic group labelled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused system substituted with ethoxycarbonyl function; (iv) and Y represents the group (A) wherein R2 and R3 are independently hydrogen; or methyl; or Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom). The compositions may be used for the treatment of tumours or other cancerous conditions, such as CML (chronic myeloid leukaemia), AML, in AIDS-related lymphomas (such as Karpowski's sarcoma, a sub-cutaneous lymphoma) and used as apoptotic agents in the treatment of cancers generally.

IPC 1-7

C07D 498/04; C07D 513/04; C07D 498/14; A61K 31/554; A61P 35/00

IPC 8 full level

A61P 35/00 (2006.01); C07D 498/04 (2006.01); C07D 498/14 (2006.01); C07D 513/04 (2006.01)

CPC (source: EP)

A61P 35/00 (2017.12); C07D 513/04 (2013.01)

Citation (search report)

See references of WO 0158904A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0158904 A1 20010816; WO 0158904 A9 20020221; AU 3218501 A 20010820; CA 2400102 A1 20010816; EP 1255758 A1 20021113; IE 20000120 A1 20030305; NZ 520884 A 20040528

DOCDB simple family (application)

IE 0100020 W 20010209; AU 3218501 A 20010209; CA 2400102 A 20010209; EP 01904273 A 20010209; IE 20000120 A 20000211; NZ 52088401 A 20010209