Global Patent Index - EP 1255758 A1

EP 1255758 A1 2002-11-13 - APOPTOSIS-INDUCING COMPOUNDS

Title (en)

APOPTOSIS-INDUCING COMPOUNDS

Title (de)

APOPTOSE-INDUZIERENDE VERBINDUNGEN

Title (fr)

COMPOSES INDUISANT L'APOPTOSE

Publication

EP 1255758 A1 (EN)

Application

EP 01904273 A

Priority

  • IE 0100020 W
  • IE 20000120 A

Abstract (en)

[origin: WO0158904A1] The invention relates to a pharmaceutical composition comprising an apoptosis-inducing amount of a compound having general formula (I), wherein: (i) R1 represents an unsubstituted C6 or C10 aryl group; or a C6 aryl group substituted with Me or OMe; (ii) A represents O, S or S partially oxidized to sulfoxide; (iii) the cyclic group labelled F represents an unsubstituted C6 or C10 aryl-fused group or a C5 heteroaryl-fused group (nitrogen as heteroatom) or a benzo-fused system substituted with ethoxycarbonyl function; (iv) and Y represents the group (A) wherein R2 and R3 are independently hydrogen; or methyl; or Y represents the group CH3 or a (CH2)2CH3 group; or an unsubstituted C5 heteroaryl group (nitrogen as heteroatom). The compositions may be used for the treatment of tumours or other cancerous conditions, such as CML (chronic myeloid leukaemia), AML, in AIDS-related lymphomas (such as Karpowski's sarcoma, a sub-cutaneous lymphoma) and used as apoptotic agents in the treatment of cancers generally.

IPC 1-7 (main, further and additional classification)

C07D 498/04; A61K 31/554; A61P 35/00; C07D 498/14; C07D 513/04

IPC 8 full level (invention and additional information)

A61P 35/00 (2006.01); C07D 498/04 (2006.01); C07D 498/14 (2006.01); C07D 513/04 (2006.01)

CPC (invention and additional information)

C07D 513/04 (2013.01)

Citation (search report)

See references of WO 0158904A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0158904 A1 20010816; WO 0158904 A9 20020221; AU 3218501 A 20010820; CA 2400102 A1 20010816; EP 1255758 A1 20021113; IE 20000120 A1 20030305; NZ 520884 A 20040528

INPADOC legal status


2005-11-30 [18R] REFUSED

- Effective date: 20050618

2003-01-29 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021217

2002-11-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020829

2002-11-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020829;LT PAYMENT 20020829;LV PAYMENT 20020829;MK PAYMENT 20020829;RO PAYMENT 20020829;SI PAYMENT 20020829