Global Patent Index - EP 1255781 A1

EP 1255781 A1 2002-11-13 - ANTIBODY BINDING SUPERFICIAL ZONE PROTEIN AND THEIR USES IN DIAGNOSIS AND SCREENING METHODS

Title (en)

ANTIBODY BINDING SUPERFICIAL ZONE PROTEIN AND THEIR USES IN DIAGNOSIS AND SCREENING METHODS

Title (de)

ANTIKÖRPER GEGEN DAS "SUPERFICIAL ZONE PROTEIN" UND IHRE VERWENDUNG IN NACHWEISVERFAHREN

Title (fr)

PROTEINES DE ZONE SUPERFICIELLE LIEES A UN ANTICORPS ET LEURS UTILISATIONS DANS LE CADRE DE PROCEDES DE FILTRAGE ET DE DIAGNOSTIC

Publication

EP 1255781 A1 (EN)

Application

EP 01909099 A

Priority

  • GB 0003092 A
  • US 0104372 W
  • US 18137700 P
  • US 20198900 P

Abstract (en)

[origin: WO0158958A1] The invention provides an antibody or a fragment thereof having specific binding affinity for superficial zone protein (SZP) or a variant, fragment, or protein core thereof, wherein the binding affinity of the antibody or fragment thereof for human superficial zone protein is the same or greater than the binding affinity for bovine superficial zone protein in a competitive binding assay, IAsys analysis, or BIAcore analysis. The present invention further provides hybidoma cells that produce the monoclonal antibody and antibody reagent kits comprising the antibody or fragment of the invention. Further provided by the invention are methods of SZP detection, methods of diagnosing a degenerative joint condition, and screening methods related to the use of the antibody or fragment thereof.

IPC 1-7 (main, further and additional classification)

C07K 16/18; C12N 5/20; G01N 33/68

IPC 8 full level (invention and additional information)

C07K 16/18 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

C07K 16/18 (2013.01); G01N 33/6887 (2013.01); A61K 2039/53 (2013.01); C12N 2799/026 (2013.01); G01N 2500/00 (2013.01); G01N 2800/105 (2013.01); G01N 2800/52 (2013.01)

Citation (search report)

See references of WO 0158958A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0158958 A1 20010816; WO 0158958 A9 20021017; EP 1255781 A1 20021113

INPADOC legal status


2007-02-28 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20060901

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: HUTCHINS, JEFF, T.

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: KUETTNER, KLAUS E.,RUSH-PRESBYTERIAN ST. LUK'E MC

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LINDLEY, KATHRYN MASON,GLAXOSMITHKLINE

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCHMID, THOMAS M.,RUSH-PRESBYTERIAN ST.LUKE'S MC

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SCHUMACHER, BARBARA, L.

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: STIMPSON, STEPHEN ANTHONY,GLAXOSMITHKLINE

2003-03-12 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SU, JUI-LAN,GLAXOSMITHKLINE

2002-11-13 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020830

2002-11-13 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-13 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI