EP 1255828 A2 20021113 - SMALL OLIGONUCLEOTIDES WITH ANTI-TUMOR ACTIVITY
Title (en)
SMALL OLIGONUCLEOTIDES WITH ANTI-TUMOR ACTIVITY
Title (de)
KURZE OLIGONUKLEOTIDE MIT ANTITUMOR-WIRKUNG
Title (fr)
PETITS OLIGONUCLEOTIDES EXER ANT UNE ACTIVITE ANTITUMORALE
Publication
Application
Priority
- US 0140159 W 20010220
- US 50697900 A 20000218
Abstract (en)
[origin: WO0160998A2] The present invention provides short antisense oligonucleotide compositions and methods for their use in the treatment of Bcl-2-associated diseases like cancer, such as follicular lymphoma (FL). The antisense oligonucleotides contain sequences that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. The use of novel short antisense oligonucleotides, from 7 bases to 9 bases in length, is described in this invention. The invention also describes certain specific sequences which are longer than 9 bases and are 11 or 15 bases long. Used alone, or in conjunction with other antisense oligonucleotides, these antisense oligonucleotide compositions inhibit the proliferation of cancer cells.
IPC 1-7
IPC 8 full level
A61P 35/00 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 9/127 (2006.01); A61K 38/00 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP US)
A61P 35/00 (2017.12 - EP); C12N 15/1135 (2013.01 - EP US); A61K 9/127 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); A61K 2123/00 (2013.01 - EP US); C12N 2310/311 (2013.01 - EP US); C12N 2310/315 (2013.01 - EP US)
Citation (search report)
See references of WO 0160998A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0160998 A2 20010823; WO 0160998 A3 20020228; WO 0160998 A9 20080717; CA 2398945 A1 20010823; EP 1255828 A2 20021113; US 7704962 B1 20100427
DOCDB simple family (application)
US 0140159 W 20010220; CA 2398945 A 20010220; EP 01927361 A 20010220; US 50697900 A 20000218