EP 1255830 A2 20021113 - CBP86, A SPERM SPECIFIC PROTEIN
Title (en)
CBP86, A SPERM SPECIFIC PROTEIN
Title (de)
CBP86, EIN SPERMIEN-SPEZIFISCHES PROTEIN
Title (fr)
CBP86, PROTEINE SPECIFIQUE DU SPERME
Publication
Application
Priority
- US 0101715 W 20010119
- US 17688700 P 20000119
Abstract (en)
[origin: WO0153338A2] The present invention relates to acidic (pI 4.0) 86 kDA isoforms of a novel, polymorphic, testis-specific protein designated calcium binding protein 86 (CBP86). This protein is tyrosine phosphorylated during <i>in vitro</i>capacitation and bound calcium<45> on 2-D gels, the latter effect abolished by dephosphorylation with alkaline phosphatase. CBP86 localizes to the principal piece of the human sperm flagellum in association with the fibrous sheath and is the first demonstration of a sperm protein that both oligomerizes and gains calcium binding capacity in a tyrosine phosphorylation dependent manner during capacitation.
IPC 1-7
C12N 15/12; C07K 14/47; C12N 5/10; G01N 33/68; C07K 16/18; C12Q 1/02
IPC 8 full level
C07K 14/47 (2006.01); C07K 16/18 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
C07K 14/4728 (2013.01)
Citation (search report)
See references of WO 0153338A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0153338 A2 20010726; WO 0153338 A3 20020221; AU 2795001 A 20010731; CA 2397901 A1 20010726; EP 1255830 A2 20021113; JP 2003520589 A 20030708
DOCDB simple family (application)
US 0101715 W 20010119; AU 2795001 A 20010119; CA 2397901 A 20010119; EP 01902116 A 20010119; JP 2001553810 A 20010119