EP 1255836 A2 20021113 - NOVEL, CENTRAL NERVOUS PROTEIN, THAT MODULATES K?+ FLOWS
Title (en)
NOVEL, CENTRAL NERVOUS PROTEIN, THAT MODULATES K?+ FLOWS
Title (de)
ZENTRALNERVÖSES PROTEIN, DAS K+-STRÖME MODULIERT
Title (fr)
NOUVELLE PROTEINE DU SYSTEME NERVEUX CENTRAL, QUI MODULE LES FLUX DE K?+
Publication
Application
Priority
- DE 10007468 A 20000218
- EP 0101730 W 20010215
Abstract (en)
[origin: WO0161001A2] The invention relates to nucleic acid sequences and isolated proteins which are novel interaction partners of inwardly rectifying potassium channels (Kirs), especially G protein-coupled inwardly rectifying potassium channels (GIRKs). Said interaction partners, together with the Kirs or GIRKs, form protein complexes. The invention also relates to a charged domain of the inventive interaction partners. Said domain binds to the complex intracellular area of Kirs and influences the activity of Kirs in general or of GIRKs in particular. The invention further relates to protein complexes of interaction partners and inwardly rectifying potassium channels, nucleic acid sequences or recombinant nucleic acid constructs which code for such proteins or domains and to the use thereof. The invention relates to protein complexes consisting of the inventive protein and further proteins. The invention also relates to host organisms and specially transgenic animals which contain the inventive nucleic acid sequences or the recombinant nucleic acid constructs as well as to mono- or polyclonal antibodies which are directed against the isolated proteins. The invention further relates to methods for finding partners, i.e. low-molecular or high-molecular substances that specifically bind to the inventive interaction partners.
IPC 1-7
C12N 15/12; C12N 15/10; C12N 15/66; C07K 14/705; C07K 16/28; A01K 67/027; A61K 39/395; A61K 38/17; G01N 33/53; G01N 33/566; C12Q 1/68
IPC 8 full level
C07K 14/705 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01)
Citation (search report)
See references of WO 0161001A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0161001 A2 20010823; WO 0161001 A3 20020314; WO 0161001 A9 20020808; AU 5032201 A 20010827; DE 10007468 A1 20010823; EP 1255836 A2 20021113
DOCDB simple family (application)
EP 0101730 W 20010215; AU 5032201 A 20010215; DE 10007468 A 20000218; EP 01923582 A 20010215