EP 1255849 A2 20021113 - RECOMBINANT RHABDOVIRUSES AS LIVE-VIRAL VACCINES FOR IMMUNODEFICIENCY VIRUSES
Title (en)
RECOMBINANT RHABDOVIRUSES AS LIVE-VIRAL VACCINES FOR IMMUNODEFICIENCY VIRUSES
Title (de)
REKOMBINANTE RHABDOVIREN ALS LEBENDIMPFSTOFFE GEGEN IMMUNSCHWäCHE-VIREN
Title (fr)
RHABDOVIRUS RECOMBINES UTILES EN TANT QUE VACCINS A VIRUS VIVANTS DIRIGES CONTRE DES VIRUS A DEFICIT IMMUNITAIRE
Publication
Application
Priority
- US 0101989 W 20010122
- US 49426200 A 20000128
Abstract (en)
[origin: WO0155330A2] This invention provides recombinant, replication-competent Rhabdovirus vaccine strain-based expression vectors for expressing heterologous viral antigenic polypeptides such as immunodeficiency virus envelope proteins or subparts thereof. An additional transcription stop/start unit within the Rhabdovirus genome is inserted to express the heterologous antigenic polypeptides. The HIV-1 gp160 protein is stably and functionally expressed, as indicated by fusion of human T cell-lines after infection with the recombinant RVs. Inoculation of mice with the recombinant Rabies viruses expressing HIV-1 gp160 induces a strong humoral response directed against the HIV-1 envelope protein after a single boost with an isolated recombinant HIV-1 gp120 protein. Moreover, high neutralization titers, up to 1:800, against HIV-1 are detected in the mouse sera. These recombinant viral vectors expressing viral antigenic polypeptides provide useful and effective pharmaceutical compositions for the generation of viral-specific immune responses.
IPC 1-7
IPC 8 full level
A61K 35/76 (2006.01); A61K 39/21 (2006.01); A61K 48/00 (2006.01); A61P 31/18 (2006.01); C07K 14/16 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/86 (2006.01); A61K 39/00 (2006.01)
CPC (source: EP)
A61P 31/18 (2017.12); C07K 14/005 (2013.01); C12N 15/86 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/57 (2013.01); C07K 2319/00 (2013.01); C12N 2740/16122 (2013.01); C12N 2760/20043 (2013.01)
Citation (search report)
See references of WO 0155330A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0155330 A2 20010802; WO 0155330 A3 20020328; AU 2967701 A 20010807; CA 2396709 A1 20010802; CN 1416471 A 20030507; EP 1255849 A2 20021113; JP 2003535577 A 20031202
DOCDB simple family (application)
US 0101989 W 20010122; AU 2967701 A 20010122; CA 2396709 A 20010122; CN 01804229 A 20010122; EP 01946888 A 20010122; JP 2001561135 A 20010122