EP 1255991 A2 20021113 - DEVICE AND METHOD FOR DETECTING THE COAGULATION FUNCTIONS OF GLOBAL, ESPECIALLY PRIMARY HEMOSTASIS
Title (en)
DEVICE AND METHOD FOR DETECTING THE COAGULATION FUNCTIONS OF GLOBAL, ESPECIALLY PRIMARY HEMOSTASIS
Title (de)
VORRICHTUNG UND VERFAHREN ZUR ERFASSUNG VON GERINNUNGS-FUNKTIONEN DER GLOBALEN, INSBESONDERE DER PRIMÄREN HÄMOSTASE
Title (fr)
DISPOSITIF ET PROCEDE POUR DETERMINER LES FONCTIONS DE COAGULATION DE L'HEMOSTASE GLOBALE, NOTAMMENT PRIMAIRE
Publication
Application
Priority
- DE 10003093 A 20000125
- EP 0100763 W 20010124
Abstract (en)
[origin: EP1471353A2] Apparatus for investigating e.g. primary hemostasis comprises a feed chamber (2) and a reaction chamber (39) with a flow channel, where blood is fed through the channel by a piston and cylinder unit (1) and a pressure sensor (9) measures variations in pressure in a blood-free pressure measuring chamber (3), which are dependent on the reactions taking place in the reaction chamber. Apparatus for investigating global, especially primary hemostasis in whole blood or platelet-enriched plasma comprises a feed chamber (2) and a reaction chamber (39) with a flow channel for the blood. The blood is fed through this by a piston and cylinder unit (1). A pressure sensor (9) measures variations in pressure in a blood-free pressure measuring chamber (3), which are dependent on the reactions taking place in the reaction chamber. Blood which has passed through the reaction chamber is then fed to a collecting vessel. The pressure measuring chamber is positioned below the feed chamber and above the surface of the blood passing through the reaction chamber into the collecting vessel. An independent claim is also included for a method for investigating global, especially primary hemostasis in whole blood or platelet-enriched plasma in which blood is fed from a feed chamber through an orifice into a reaction chamber under predetermined shear or flow conditions. It is then fed on to a reaction surface where coagulation takes place (e.g. clot formation under the influence of thrombin), forming a structure composed of polymerized fibrin and cellular components (thrombocytes, erythrocytes and leukocytes) or a force is developed which is exerted by activated thrombocytes on the fibrin network in the reaction orifice. The alteration in pressure due to this is then measured. The shear rate, shear force or flow rate is then adjusted, depending on the measured pressure or blood viscosity calculated from it, to conform to a predetermined value.
IPC 1-7
IPC 8 full level
G01N 33/86 (2006.01); G01N 33/49 (2006.01); G01N 11/08 (2006.01)
CPC (source: EP US)
G01N 33/4905 (2013.01 - EP US); G01N 11/08 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
US 2003130596 A1 20030710; US 7223365 B2 20070529; AT E434182 T1 20090715; AU 3922801 A 20010807; DE 10003093 A1 20010802; DE 10003093 C2 20020516; DE 50114942 D1 20090730; EP 1255991 A2 20021113; EP 1471353 A2 20041027; EP 1471353 A3 20050817; EP 1471353 B1 20090617; ES 2328690 T3 20091117; JP 2003524780 A 20030819; JP 4602626 B2 20101222; WO 0155715 A2 20010802; WO 0155715 A3 20020314
DOCDB simple family (application)
US 18223802 A 20021118; AT 04017857 T 20010124; AU 3922801 A 20010124; DE 10003093 A 20000125; DE 50114942 T 20010124; EP 0100763 W 20010124; EP 01913766 A 20010124; EP 04017857 A 20010124; ES 04017857 T 20010124; JP 2001555805 A 20010124