EP 1257654 A1 20021120 - M CELL DIRECTED VACCINES
Title (en)
M CELL DIRECTED VACCINES
Title (de)
IMPFSTOFFE MIT SPEZIFITÄT FÜR M ZELLEN
Title (fr)
VACCINS AGISSANT SUR LES CELLULES M
Publication
Application
Priority
- US 0100426 W 20010108
- US 17478600 P 20000106
Abstract (en)
[origin: WO0149867A1] This invention provides a vaccine that can direct gene transfer to follicle associated epithelium or M cells to induce mucosal immunity using M cell ligands for receptor-mediated endocytosis. Also provided are polynucleotides sequences encoding M cell ligand-polybasic component fusion proteins, host cells, and methods of producing such proteins recombinantly and chemically. Further, methods are described for immunizing animal and human subjects against bacterial, viral, parasitic, fungal infectious agents or cancer and methods for assaying mucosal immunity using this vaccine.
IPC 1-7
C12N 15/62; C12N 5/10; C07K 14/105; C07K 14/255; C07K 14/14; C07K 19/00; C07K 16/18; C07K 16/10; C12N 15/87; C12N 15/11; G01N 33/53; A61K 39/00; A61K 48/00
IPC 8 full level
A61K 47/48 (2006.01); C07K 14/105 (2006.01); C07K 14/14 (2006.01); C07K 14/255 (2006.01); C07K 19/00 (2006.01)
CPC (source: EP)
A61K 47/646 (2017.07); C07K 14/005 (2013.01); C07K 14/255 (2013.01); C07K 19/00 (2013.01); C07K 2319/00 (2013.01); C12N 2720/12022 (2013.01); C12N 2770/32622 (2013.01)
Citation (search report)
See references of WO 0149867A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0149867 A1 20010712; AU 2767201 A 20010716; EP 1257654 A1 20021120
DOCDB simple family (application)
US 0100426 W 20010108; AU 2767201 A 20010108; EP 01901811 A 20010108