Global Patent Index - EP 1257661 A1

EP 1257661 A1 2002-11-20 - AN ASSAY FOR DETECTING VARIANT HAPATITIS B VIRUSES (HBVs) WHICH EXHIBIT ALTERED SENSITIVITY TO AGENTS

Title (en)

AN ASSAY FOR DETECTING VARIANT HAPATITIS B VIRUSES (HBVs) WHICH EXHIBIT ALTERED SENSITIVITY TO AGENTS

Title (de)

ASSAY ZUM NACHWEIS VON VARIANTEN DES HEPATITIS B VIRUS (HBVS) WELCHE VERÄNDERTE SENSITIVITÄT ZU AGENZIEN AUFWEISEN

Title (fr)

TEST DE DETECTION DE VIRUS D'HEPATITE B VARIANTS MONTRANT UNE REPONSE DEFICIENTE AUX AGENTS

Publication

EP 1257661 A1 (EN)

Application

EP 01903503 A

Priority

  • AU 0100098 W
  • US 17994800 P

Abstract (en)

[origin: WO0157244A1] The present invention relates generally to an assay for detecting variant Hepatitis B viruses (HBVs) which exhibit altered sensitivity to agents. The variant HBVs are delivered to cells using a baculovirus vector. The same agents generally have a particular effect or absence of effect on a reference HBV. The altered sensitivity is in relation to the effects of the agent on one or more stages of infection, replication, assembly or release of virus or virus-like particles including any intermediary steps during the processes of viral infection, replication, assembly and/or release. The identification of variant HBVs with altered sensitivities to anti-HBV agents provides a means of monitoring cross resistance, or the development of new therapeutics effective against variant HBVs with altered sensitivities to other anti-HBV agents, as well as monitoring therapeutic protocols which may then need to be modified to ensure the appropriate anti-HBV agent is administered or that the appropriate therapeutic protocol is instituted. The present invention further provides variant HBVs detected by the assay of the present invention and to components thereof as well as recombinant, chemical analogue, homologue and derivative forms of such components.

IPC 1-7 (main, further and additional classification)

C12Q 1/48; C12Q 1/70

IPC 8 full level (invention and additional information)

C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/48 (2006.01); G01N 33/576 (2006.01)

CPC (invention and additional information)

G01N 33/5761 (2013.01); G01N 2800/52 (2013.01)

Citation (search report)

See references of WO 0157244A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0157244 A1 20010809; AU 3141501 A 20010814; EP 1257661 A1 20021120; JP 2003521249 A 20030715

INPADOC legal status


2006-03-22 [18R] REFUSED

- Effective date: 20050527

2002-11-20 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020902

2002-11-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-20 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL PAYMENT 20020902;LT PAYMENT 20020902;LV PAYMENT 20020902;MK PAYMENT 20020902;RO PAYMENT 20020902;SI PAYMENT 20020902