Global Patent Index - EP 1257665 A2

EP 1257665 A2 2002-11-20 - LIBRARIES OF OPTIMUM SUBSEQUENCE REGIONS OF mRNA AND GENOMIC DNA FOR CONTROL OF GENE EXPRESSION

Title (en)

LIBRARIES OF OPTIMUM SUBSEQUENCE REGIONS OF mRNA AND GENOMIC DNA FOR CONTROL OF GENE EXPRESSION

Title (de)

BIBLIOTHEKEN VON OPTIMALEN UNTERSEQUENZREGIONEN VON mRNA UND GENOMISCHER DNA ZUR KONTROLLE DER GENEXPRESSION

Title (fr)

BIBLIOTHEQUES DE REGIONS DE SOUS-SEQUENCES OPTIMALES D'ARNM ET D'ADN GENOMIQUE POUR LA REGULATION DE L'EXPRESSION GENETIQUE

Publication

EP 1257665 A2 (EN)

Application

EP 01907219 A

Priority

  • US 0104732 W
  • US 50465300 A

Abstract (en)

[origin: WO0161030A2] The invention discloses a method for selecting optimal subsequence antisense targets for preparing an antisense oligonucleotide capable of inhibiting mRNA expression of target mRNA sequences, as well as antisense oligonucleotides capable of binding DNA. These libraries of antisense molecules may then be used for preparing therapeutic agents for the treatment of genetic disease. Antigene sequences specific for a desired target gene sequence and having mRNA, protein or cell growth inhibition efficiencies may then be used to control DNA expression. By in no way intending to be limited to any particular gene, examples of these human genes of interest in which mRNA subsequence targets will be identified and antisense molecules prepared are: c-Myc, c-Myb, Bcl-2, c-Raf, Cyclin D1, IGF-IR, PKC alpha , or CA12 genes. Antisense oligonucleotides of the invention may in some embodiments be at least 50 nucleotides in length. Examples include antisense oligonucleotides that specifically bind human protein kinase C-alpha and human C-Raf protein kinase.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C12N 15/10; C12N 15/11

IPC 8 full level (invention and additional information)

C12N 15/10 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12Q 1/00 (2006.01); C12Q 1/68 (2006.01)

CPC (invention and additional information)

C12N 15/113 (2013.01); C12N 15/111 (2013.01); C12N 15/1131 (2013.01); C12N 15/1135 (2013.01); C12N 15/1137 (2013.01); C12N 15/1138 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2320/11 (2013.01)

Citation (search report)

See references of WO 0161030A3

Designated contracting state (EPC)

AT BE CH DE FR GB LI

EPO simple patent family

WO 0161030 A2 20010823; WO 0161030 A3 20020829; AU 3501901 A 20010827; CA 2400028 A1 20010823; EP 1257665 A2 20021120

INPADOC legal status


2005-03-16 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040831

2004-05-12 [RBV] DESIGNATED CONTRACTING STATES (CORRECTION):

- Designated State(s): AT BE CH DE FR GB LI

2002-11-20 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020909

2002-11-20 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-20 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL;LT;LV;MK;RO;SI