Global Patent Index - EP 1259121 A2

EP 1259121 A2 2002-11-27 - WEIGHT LOSS INDUCED BY REDUCTION IN NEUROPEPTIDE Y LEVEL

Title (en)

WEIGHT LOSS INDUCED BY REDUCTION IN NEUROPEPTIDE Y LEVEL

Title (de)

GEWICHTABNAHME, INDUZIERT DURCH REDUZIERUNG DES NEUROPEPTID-Y-SPIEGELS

Title (fr)

PERTE DE POIDS INDUITE PAR LA REDUCTION DU NIVEAU DE NEUROPEPTIDE Y

Publication

EP 1259121 A2 (EN)

Application

EP 01910959 A

Priority

  • US 0105316 W
  • US 18290100 P
  • US 20856000 P

Abstract (en)

[origin: WO0160174A2] This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted alpha -methylene- beta -carboxyl- gamma -butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.

IPC 1-7 (main, further and additional classification)

A23K 1/00

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); A61K 31/00 (2006.01); A61K 31/365 (2006.01); A61K 45/00 (2006.01); A61P 3/04 (2006.01); A61P 43/00 (2006.01); C07D 307/68 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01)

CPC (invention and additional information)

A61K 31/365 (2013.01); A61K 31/00 (2013.01); G01N 2333/5755 (2013.01)

Citation (search report)

See references of WO 0160174A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0160174 A2 20010823; WO 0160174 A3 20020425; AU 3851501 A 20010827; CA 2400136 A1 20010823; EP 1259121 A2 20021127; JP 2003528051 A 20030924; KR 20030016228 A 20030226

INPADOC legal status


2005-02-16 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20040813

2004-03-17 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040202

2002-11-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020916

2002-11-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-27 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI