EP 1259121 A2 20021127 - WEIGHT LOSS INDUCED BY REDUCTION IN NEUROPEPTIDE Y LEVEL
Title (en)
WEIGHT LOSS INDUCED BY REDUCTION IN NEUROPEPTIDE Y LEVEL
Title (de)
GEWICHTABNAHME, INDUZIERT DURCH REDUZIERUNG DES NEUROPEPTID-Y-SPIEGELS
Title (fr)
PERTE DE POIDS INDUITE PAR LA REDUCTION DU NIVEAU DE NEUROPEPTIDE Y
Publication
Application
Priority
- US 0105316 W 20010216
- US 18290100 P 20000216
- US 20856000 P 20000602
Abstract (en)
[origin: WO0160174A2] This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect may be accomplished directly, indirectly or humorally. Preferably, administration of this compound has the effect of increasing malonyl CoA levels in the animal. Compounds administered according to this invention may be inhibitors of fatty acid synthase (FAS), including substituted alpha -methylene- beta -carboxyl- gamma -butyrolactones, or inhibitors of malonyl Coenzyme A decarboxylase (MCD). Preferably, the compound is administered in an amount sufficient to reduce the amount and/or duration of expression and/or secretion of NPY to levels at or below those observed for lean animals. In another preferred embodiment, the administration will reduce expression and/or secretion to levels observed for fed or satiated animals; more preferably, administration will reduce the level of NPY below that of fed animals. In a particular embodiment, this invention provides a method for inducing weight loss in an animal by administering a compound which inhibits feeding behavior in the animal. The method is particularly useful for inducing weight loss in animals deficient in expression of the hormone leptin or animals resistant to the action of leptin.
IPC 1-7
IPC 8 full level
A61K 31/00 (2006.01); A61K 31/365 (2006.01); A61K 45/00 (2006.01); A61P 3/04 (2006.01); A61P 43/00 (2006.01); C07D 307/68 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - EP); A61K 31/365 (2013.01 - EP KR); A61P 3/04 (2017.12 - EP); A61P 43/00 (2017.12 - EP); G01N 2333/5755 (2013.01 - EP)
Citation (search report)
See references of WO 0160174A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0160174 A2 20010823; WO 0160174 A3 20020425; AU 3851501 A 20010827; CA 2400136 A1 20010823; EP 1259121 A2 20021127; JP 2003528051 A 20030924; KR 20030016228 A 20030226
DOCDB simple family (application)
US 0105316 W 20010216; AU 3851501 A 20010216; CA 2400136 A 20010216; EP 01910959 A 20010216; JP 2001559278 A 20010216; KR 20027010680 A 20020816