Title (en)

METHOD FOR IDENTIFYING AN AGENT FOR TREATMENT OF NIDDMDIABETES BY INTERACTION WITH COMPOUND U0126

Title (de)

VERFAHREN ZUR IDENTIFIZIERUNG EINES MITTELS ZUR BEHANDLUNG VON NIDD-DIABETES DURCH INTERAKTION MIT EINER UO126-VERBINDUNG

Title (fr)

PROCEDE D'IDENTIFICATION D'UN AGENT POUR LE TRAITEMENT DU DIABETE DNID PAR INTERACTION AVEC UN COMPOSE UO126

Publication

EP 1259232 A1 20021127 (EN)

Application

EP 01912628 A 20010302

Priority

• SE 0100450 W 20010302
• SE 0000718 A 20000303

Abstract (en)

[origin: WO0164209A1] The present invention relates to a method for identifying an agent useful for the treatment or prevention of a medical condition related to reduced cellular uptake of glucose, said method comprising the steps of: (i) identifying a target polypeptide interacting with the compound U0126 (1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene); (ii) contacting a candidate agent with the said target polypeptide; and (iii) determining whether said candidate agent modulates the biological activities of the said target polypeptide, such modulation being indicative for an agent useful for the treatment or prevention of a medical condition related to reduced cellular uptake of glucose.

IPC 1-7

A61K 31/145; A61P 3/10

IPC 8 full level

C12Q 1/02 (2006.01); C12Q 1/48 (2006.01); C12Q 1/54 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/566 (2006.01); G01N 33/66 (2006.01)

CPC (source: EP)

A61P 3/10 (2017.12); C12Q 1/485 (2013.01); G01N 33/66 (2013.01)

Citation (search report)

See references of WO 0164209A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0164209 A1 20010907; AU 4131601 A 20010912; CA 2399889 A1 20010907; EP 1259232 A1 20021127; JP 2003525431 A 20030826; SE 0000718 D0 20000303

DOCDB simple family (application)

SE 0100450 W 20010302; AU 4131601 A 20010302; CA 2399889 A 20010302; EP 01912628 A 20010302; JP 2001563106 A 20010302; SE 0000718 A 20000303