Global Patent Index - EP 1259650 A2

EP 1259650 A2 2002-11-27 - ESTROGEN RECEPTOR ALPHA VARIANTS AND METHODS OF DETECTION THEREOF

Title (en)

ESTROGEN RECEPTOR ALPHA VARIANTS AND METHODS OF DETECTION THEREOF

Title (de)

ÖSTROGENREZEPTOR ALPHA VARIANTEN UND VERFAHREN ZUR DETEKTION DERSELBEN

Title (fr)

VARIANTS DE RECEPTEURS OESTROGENIQUES ALPHA ET PROCEDE DE DETECTION DESDITS VARIANTS

Publication

EP 1259650 A2 (EN)

Application

EP 01916135 A

Priority

  • US 0105358 W
  • US 18375600 P
  • US 69241400 A
  • US 76818401 A

Abstract (en)

[origin: WO0162969A2] The present invention is based on sequencing genomic DNA from human chromosome 6 and cDNAs to define the genomic structure of estrogen receptor alpha genes and novel polymorphism/haplotypes in the estrogen receptor gene/protein. Such polymorphism/haplotypes can lead to a variety of disorders that are mediated/modulated by a variant estrogen receptor, such as a susceptibility to cancer, osteoporosis, cardiovascular disorder, etc. Based on this sequencing approach, the present invention provides genomic nucleotide sequences, cDNA sequences, amino acid sequences and sequence polymorphism/haplotypes in the ESR-alpha genes, methods of detecting these sequences/polymorphism/haplotypes in a sample, methods of determining a risk of having or developing a disorder mediated by a variant estrogen receptor and methods of screening for compounds used to treat disorders mediated by a variant estrogen receptor.

IPC 1-7 (main, further and additional classification)

C12Q 1/68; C07K 14/705; C07K 16/28; C12N 5/10

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C07K 16/28 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)

CPC (invention and additional information)

C07K 14/70567 (2013.01); C12Q 1/68 (2013.01)

Citation (search report)

See references of WO 0162969A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

WO 0162969 A2 20010830; WO 0162969 A3 20020314; AU 4319601 A 20010903; CA 2400915 A1 20010830; EP 1259650 A2 20021127; JP 2004537959 A 20041224

INPADOC legal status


2007-02-21 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20060902

2004-09-08 [RAP1] TRANSFER OF RIGHTS OF AN APPLICATION

- Owner name: APPLERA CORPORATION

2002-11-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020919

2002-11-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-11-27 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI