Global Patent Index - EP 1259824 A1

EP 1259824 A1 2002-11-27 - TRISOMY 21 CYTOTROPHOBLAST CULTURES, AND USES THEREOF FOR OBTAINING TRISOMY 21 MARKERS

Title (en)

TRISOMY 21 CYTOTROPHOBLAST CULTURES, AND USES THEREOF FOR OBTAINING TRISOMY 21 MARKERS

Title (de)

TRISOMY-21 ZYTOTROPHOBLAST ZELLKULTUREN UND DEREN VERWENDUNG ZUR ERLANGUNG VON TRISOMY-21 MARKER

Title (fr)

CULTURES DE CYTOTROPHOBLASTES DE TRISOMIE 21, ET LEUR UTILISATION POUR L'OBTENTION DE MARQUEURS DE LA TRISOMIE 21

Publication

EP 1259824 A1 (FR)

Application

EP 01913925 A

Priority

  • FR 0100619 W
  • FR 0002795 A

Abstract (en)

[origin: FR2805824A1] Culturing cytotrophoblasts, (A), that are trisomic for human chromosome 21, or for a region of this that contains at least the gene encoding copper-zinc superoxide dismutase, after 3 days of culture, (A) express at least one peptide hormone (I) at below the mean level for normal placental cytotrophoblasts at the same stage of gestation and cultured under the same conditions, is new. Where (I) are human placental lactogen (hPL), human chorionic gonadotropin (hCG) alpha or beta human placental growth hormone (PGH) and/or leptin. Independent claims are also included for the following: (1) differential expression libraries of nucleic acid prepared from at least one culture of (A); and (2) determining the risk of trisomy 21 in a fetus.

IPC 1-7 (main, further and additional classification)

G01N 33/74; C12N 5/06

IPC 8 full level (invention and additional information)

C12N 5/073 (2010.01); C12Q 1/00 (2006.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01)

CPC (invention and additional information)

C12N 5/0605 (2013.01); G01N 33/6893 (2013.01); G01N 33/74 (2013.01); C12N 2503/00 (2013.01); G01N 2800/36 (2013.01); G01N 2800/387 (2013.01)

Citation (search report)

See references of WO 0165264A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

FR 2805824 A1 20010907; FR 2805824 B1 20020503; CA 2401603 A1 20010907; EP 1259824 A1 20021127; JP 2003525056 A 20030826; US 2003138435 A1 20030724; WO 0165264 A1 20010907

INPADOC legal status


2009-05-06 [18R] REFUSED

- Effective date: 20081225

2002-11-27 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020831

2002-11-27 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR