EP 1261323 A2 20021204 - METHOD OF TREATING GASTROINTESTINAL TRACT DISEASE WITH PURINERGIC RECEPTOR AGONISTS
Title (en)
METHOD OF TREATING GASTROINTESTINAL TRACT DISEASE WITH PURINERGIC RECEPTOR AGONISTS
Title (de)
VERFAHREN ZUR BEHANDLUNG VON MAGEN-DARM TRAKTSERKRANKUNGEN MIT PURIN-REZEPTORAGONISTEN
Title (fr)
METHODE DE TRAITEMENT DE MALADIES DU TRACTUS GASTRO-INTESTINAL AU MOYEN D'AGONISTES DE RECEPTEURS PURINERGIQUES
Publication
Application
Priority
- US 0035439 W 20001222
- US 17171099 P 19991222
Abstract (en)
[origin: WO0145691A2] The invention provides a method of regulating water and mucin secretions and fluid transport in the gastrointestinal tract. The invention also provides a method for treating a gastrointestinal disease in which the mucosal barrier of the gastrointestinal system is impaired. The invention additionally provides a method for correcting disorders of fluid secretion or absorption in the gastrointestinal system. The method comprises administering to a patient a pharmaceutical composition comprising a purinergic P2Y receptor agonist, in an amount effective to regulate water and mucin secretions or to correct abnormal fluid transport in the gastrointestinal tract. The pharmaceutical composition used in this invention comprises a P2Y purinergic receptor agonist such as uridine 5'-diphosphate (UDP), uridine 5'-triphosphate (UTP), cytidine 5'-diphosphate (CDP), cytidine 5'-triphosphate (CTP), adenosine 5'-diphosphate (ADP), adenosine 5'-triphosphate (ATP), and their analogs; and dinucleotide polyphosphate compounds of general Formula (IV). Said compound is prepared in an oral form, an injectable form, or a suppository form, and administered to a patient.
IPC 1-7
IPC 8 full level
C07H 19/048 (2006.01); A61K 9/02 (2006.01); A61K 31/00 (2006.01); A61K 31/706 (2006.01); A61K 31/7068 (2006.01); A61K 31/7072 (2006.01); A61K 31/7076 (2006.01); A61K 31/708 (2006.01); A61K 31/7084 (2006.01); A61K 45/00 (2006.01); A61P 1/00 (2006.01); A61P 1/02 (2006.01); A61P 1/04 (2006.01); A61P 1/10 (2006.01); A61P 1/12 (2006.01); A61P 31/10 (2006.01); A61P 43/00 (2006.01); C07H 19/10 (2006.01); C07H 19/20 (2006.01); C07H 19/207 (2006.01)
CPC (source: EP KR)
A61K 31/00 (2013.01 - EP); A61K 31/7068 (2013.01 - EP); A61K 31/7072 (2013.01 - EP); A61K 31/7076 (2013.01 - KR); A61K 31/7084 (2013.01 - EP); A61P 1/00 (2017.12 - EP); A61P 1/02 (2017.12 - EP); A61P 1/04 (2017.12 - EP); A61P 1/10 (2017.12 - EP); A61P 1/12 (2017.12 - EP); A61P 31/10 (2017.12 - EP); A61P 43/00 (2017.12 - EP)
Citation (search report)
See references of WO 0145691A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0145691 A2 20010628; WO 0145691 A3 20020418; AU 2603101 A 20010703; BR 0016021 A 20030715; CA 2395108 A1 20010628; CN 1413113 A 20030423; EP 1261323 A2 20021204; JP 2003524636 A 20030819; KR 20020069218 A 20020829; MX PA02005161 A 20021209
DOCDB simple family (application)
US 0035439 W 20001222; AU 2603101 A 20001222; BR 0016021 A 20001222; CA 2395108 A 20001222; CN 00817607 A 20001222; EP 00989533 A 20001222; JP 2001546630 A 20001222; KR 20027007963 A 20020620; MX PA02005161 A 20001222