EP 1261371 A1 20021204 - MEMBRANE ESTROGEN RECEPTOR-DIRECTED TREATMENT OF CANCER
Title (en)
MEMBRANE ESTROGEN RECEPTOR-DIRECTED TREATMENT OF CANCER
Title (de)
AUF DEN MEMBRANSTÄNDIGEN ÖSTROGENREZEPTOR AUSGERICHTETE BEHANDLUNG VON KREBS
Title (fr)
TRAITEMENT DU CANCER DIRIGEE SUR LE RECEPTEUR MEMBRANAIRE DES OESTROGENES
Publication
Application
Priority
- US 0105897 W 20010223
- US 18502600 P 20000225
Abstract (en)
[origin: WO0162288A1] Methods of diagnosing and treating mammalian tumors with molecules including anti-estrogen receptor immunoglobulin polypeptides are provided. In an illustrative embodiment, anti-estrogen receptor immunoglobulin polypeptides specific to distinct epitopes of the ligand-binding domain of estrogen receptor are contacted with membrane-associated estrogen receptor under conditions which allow binding of the anti-estrogen receptor immunoglobulin polypeptide to a degree sufficient to inhibit tumor growth by inhibiting the activation of the membrane-associated estrogen receptor. Injectable compositions for treating certain mammalian tumors with monoclonal antibodies and methods for diagnosing mammalian cancers which express an estrogen receptor associated with the surface membrane of the cells are also disclosed. Further, alternate methods for blocking intracellular signal transduction emanating from the activation of membrane-associated estrogen receptor forms are also presented. These approaches also appear sufficient to inhibit tumor growth.
IPC 1-7
IPC 8 full level
A61K 45/00 (2006.01); A61K 39/395 (2006.01); A61K 47/48 (2006.01); A61K 51/00 (2006.01); A61P 15/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 47/6849 (2017.07); A61P 15/00 (2017.12); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 16/2869 (2013.01); C07K 16/32 (2013.01); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C12N 2310/315 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0162288 A1 20010830; AU 2001241710 B2 20050721; AU 4171001 A 20010903; CA 2400874 A1 20010830; EP 1261371 A1 20021204; EP 1261371 A4 20050413; JP 2003523404 A 20030805
DOCDB simple family (application)
US 0105897 W 20010223; AU 2001241710 A 20010223; AU 4171001 A 20010223; CA 2400874 A 20010223; EP 01912991 A 20010223; JP 2001561352 A 20010223