Global Patent Index - EP 1261568 A2

EP 1261568 A2 2002-12-04 - GENERATION AND SCREENING OF A DYNAMIC COMBINATORIAL LIBRARY

Title (en)

GENERATION AND SCREENING OF A DYNAMIC COMBINATORIAL LIBRARY

Title (de)

ERZEUGUNG UND SCREENEN EINER DYNAMISCHEN KOMBINATORISCHEN VERBINDUNGSBIBLIOTHEK

Title (fr)

SYNTHESE ET CRIBLAGE D'UNE BANQUE COMBINATOIRE DYNAMIQUE

Publication

EP 1261568 A2 (EN)

Application

EP 01925363 A

Priority

  • EP 01925363 A
  • EP 0102310 W
  • EP 00104236 A

Abstract (en)

[origin: EP1130009A1] The present invention concerns a method for selectively establishing a dynamic combinatorial library of ligands binding to a target which binds at least two functionalities, which method comprises the following steps: selecting a plurality of functionalities which upon combination with each other are capable of forming an antity which may bind to the at least two functionalities in the target; linking at least two identical or different functionalities by at least one spacer group allowing reversible bond formation, thus creating discrete ligands; mixing together a plurality of a different discrete ligands having different combinations of functionalities; subjecting the mixture to conditions allowing a reversible bond formation and cleavage, hence a scrambling of the formalities; analyzing the mixture obtained; adding the target to the mixture; again analyzing the mixture, comparing the results obtained and identifying the functionality combinations which are most appropriate for the formation of a bond. In a further embodiment of the invention, the target is added when the discrete ligands are mixed together, in order to be present when the scrambling takes place.

IPC 1-7 (main, further and additional classification)

C07B 61/00; C07H 15/203; G01N 33/53

IPC 8 full level (invention and additional information)

C07H 15/04 (2006.01); A61K 47/48 (2006.01); C07B 61/00 (2006.01); C07H 15/203 (2006.01); C07H 15/207 (2006.01); C07H 15/22 (2006.01); G01N 33/53 (2006.01); G01N 33/531 (2006.01)

CPC (invention and additional information)

G01N 33/531 (2013.01); C07H 15/203 (2013.01); G01N 33/5308 (2013.01); C40B 40/00 (2013.01)

Citation (third parties)

Third party :

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

EPO simple patent family

EP 1130009 A1 20010905; AU 5215001 A 20010912; EP 1261568 A2 20021204; JP 2003525259 A 20030826; US 2004043417 A1 20040304; WO 0164605 A2 20010907; WO 0164605 A3 20011227

INPADOC legal status


2007-05-30 [18D] APPLICATION DEEMED TO BE WITHDRAWN

- Effective date: 20061003

2003-04-02 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: LEHN, JEAN-MARIE,INSTITUT LE BEL

2003-04-02 [RIN1] INVENTOR CHANGED BEFORE GRANT

- Inventor name: RAMSTROEM, OLOF,ROYAL INSTITUTE OF TECHNOLOGY

2002-12-04 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20020930

2002-12-04 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

2002-12-04 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO:

- Free text: AL;LT;LV;MK;RO;SI