EP 1263765 A4 20050629 - ALTERATION OF CELLULAR BEHAVIOR BY ANTISENSE MODULATION OF mRNA PROCESSING
Title (en)
ALTERATION OF CELLULAR BEHAVIOR BY ANTISENSE MODULATION OF mRNA PROCESSING
Title (de)
VERÄNDERUNG VON ZELLVERHALTEN DURCH ANTISENSE-MODULATION BEI DER BEARBEITUNG VON MRNS
Title (fr)
MODIFICATION DE COMPORTEMENT CELLULAIRE PAR MODULATION ANTISENS DE LA MATURATION D'ARN MESSAGER
Publication
Application
Priority
US 0008174 W 20000328
Abstract (en)
[origin: WO0172765A1] The present invention provides compositions and methods for controlling the behavior of a cell, tissue or organism through antisense modulation of mRNA processing, using antisense compounds which does not support cleavage of the mRNA target.
IPC 1-7
C07H 21/02; C07H 21/04; C12Q 1/68; A01N 43/04; A61K 31/70; C12N 15/85; C12N 15/86; C12N 15/11
IPC 8 full level
A61K 31/70 (2006.01); A61K 31/7088 (2006.01); A61K 31/7125 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07H 21/02 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 31/70 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12N 15/113 (2013.01); C12N 15/1135 (2013.01); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3341 (2013.01); C12N 2310/341 (2013.01); C12N 2310/346 (2013.01); Y02P 20/582 (2015.11)
Citation (search report)
- [X] WO 0008044 A1 20000217 - ISIS PHARMACEUTICALS INC [US], et al
- [XD] SIERAKOWSKA HALINA ET AL: "Restoration of beta-globin gene expression in mammalian cells by antisense oligonucleotides that modify the aberrant splicing patterns of thalassemic pre-mRNAs", NUCLEOSIDES AND NUCLEOTIDES, vol. 16, no. 7-9, July 1997 (1997-07-01), pages 1173 - 1182, XP008042383, ISSN: 0732-8311
- [X] BAKER B F ET AL: "2'-O-(2-METHOXY)ETHYL-MODIFIED ANTI-INTERCELLULAR ADHESION MOLECULE 1 (ICAM-1) OLIGONUCLEOTIDES SELECTIVELY INCREASE THE ICAM-1 MRNA LEVEL AND INHIBIT FORMATION OF THE ICAM-1 TRANSLATION INITIATION COMPLEX IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 18, 2 May 1997 (1997-05-02), pages 11994 - 12000, XP002948752, ISSN: 0021-9258
- See references of WO 0172765A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0172765 A1 20011004; AU 2000240366 B2 20050804; AU 4036600 A 20011008; CA 2400573 A1 20011004; EP 1263765 A1 20021211; EP 1263765 A4 20050629; JP 2004509604 A 20040402
DOCDB simple family (application)
US 0008174 W 20000328; AU 2000240366 A 20000328; AU 4036600 A 20000328; CA 2400573 A 20000328; EP 00919726 A 20000328; JP 2001571696 A 20000328