EP 1266013 B1 20141015 - HEPARINASE III AND USES THEREOF
Title (en)
HEPARINASE III AND USES THEREOF
Title (de)
HEPARINASE III UND DEREN VERWENDUNGEN
Title (fr)
HEPARINASE III ET SES UTILISATIONS
Publication
Application
Priority
- US 0107464 W 20010308
- US 18784600 P 20000308
Abstract (en)
[origin: WO0166772A2] The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
IPC 8 full level
C12N 15/09 (2006.01); C12N 15/60 (2006.01); A61K 31/715 (2006.01); A61K 31/726 (2006.01); A61K 38/51 (2006.01); A61K 45/00 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); A61P 9/00 (2006.01); A61P 17/06 (2006.01); A61P 27/02 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); C08B 37/00 (2006.01); C08B 37/10 (2006.01); C12N 9/24 (2006.01); C12N 9/88 (2006.01); C12P 19/26 (2006.01); C12P 19/28 (2006.01); C12Q 1/34 (2006.01); C12Q 1/527 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A61K 31/726 (2013.01 - EP US); A61K 38/51 (2013.01 - EP US); A61P 9/00 (2017.12 - EP); A61P 17/06 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/04 (2017.12 - EP); C08B 37/0075 (2013.01 - EP US); C12N 9/88 (2013.01 - EP US); C12P 19/26 (2013.01 - EP US); C12Q 1/527 (2013.01 - EP US); G01N 2333/988 (2013.01 - EP US); G01N 2500/02 (2013.01 - EP US); Y10S 530/811 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0166772 A2 20010913; WO 0166772 A3 20020502; WO 0166772 A9 20050310; AU 2001243512 B2 20070510; AU 2001243512 C1 20080417; AU 4351201 A 20010917; CA 2402160 A1 20010913; CA 2402160 C 20120214; EP 1266013 A2 20021218; EP 1266013 B1 20141015; ES 2527853 T3 20150130; JP 2003525946 A 20030902; US 2002122793 A1 20020905; US 2003099628 A1 20030529; US 2005233402 A1 20051020; US 2006067928 A1 20060330; US 2006182734 A1 20060817; US 2006183713 A1 20060817; US 2009081635 A1 20090326; US 2012027744 A1 20120202; US 6869789 B2 20050322; US 7390633 B2 20080624; US 7455986 B2 20081125; US 7939292 B2 20110510
DOCDB simple family (application)
US 0107464 W 20010308; AU 2001243512 A 20010308; AU 4351201 A 20010308; CA 2402160 A 20010308; EP 01916493 A 20010308; ES 01916493 T 20010308; JP 2001565375 A 20010308; US 18757105 A 20050722; US 201113076066 A 20110330; US 26100408 A 20081029; US 29133702 A 20021108; US 40621406 A 20060418; US 40621506 A 20060418; US 80228501 A 20010308; US 96706704 A 20041014