EP 1267898 A2 20030102 - BILE ACID CONTAINING PRODRUGS WITH ENHANCED BIOAVAILABILITY
Title (en)
BILE ACID CONTAINING PRODRUGS WITH ENHANCED BIOAVAILABILITY
Title (de)
GALLENSÄURE ENTHALTEND PROPHARMAKA MIT ERHÖHTER BIOAVIBILITÄT
Title (fr)
PROMEDICAMENTS CONTENANT UN ACIDE BILIAIRE ET PRESENTANT UNE MEILLEURE BIODISPONIBILITE
Publication
Application
Priority
- US 0111327 W 20010406
- US 19585400 P 20000407
- US 26990601 P 20010221
Abstract (en)
[origin: WO0176531A2] Many compounds have poor bioavailability or variable bioavailability because of poor absorption of the compound in the small intestine. Conjugation of the compound with bile acid to form a prodrug will increase the bioavailibility of the compound and/or reduce the bioavailability variability of the compound because of the active transport of the prodrug by the intestinal bile acid transporter and because of increased lipophilic nature of the prodrug. A linker group can be used between the bile acid and the compound. One example of a bile acid containing prodrug is acyclovir valylchenodeoxycholate, where valine is the linker group. Another example of this prodrug is atenolol cholic acid amide.
IPC 1-7
A61K 35/50; A61K 39/40; A61K 39/42; A61K 39/44; A61K 39/395; C07J 43/00; C07J 9/00; C07J 41/00; A61P 31/12
IPC 8 full level
A61K 47/48 (2006.01); A61K 31/165 (2006.01); A61K 31/522 (2006.01); A61K 31/575 (2006.01); A61K 31/58 (2006.01); A61K 35/50 (2006.01); A61K 39/395 (2006.01); A61K 39/40 (2006.01); A61K 39/42 (2006.01); A61K 39/44 (2006.01); A61P 9/04 (2006.01); A61P 31/12 (2006.01); A61P 43/00 (2006.01); C07J 9/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01)
IPC 8 main group level
A61K (2006.01)
CPC (source: EP)
A61K 47/554 (2017.07); A61P 9/04 (2017.12); A61P 31/12 (2017.12); A61P 43/00 (2017.12); C07J 9/005 (2013.01); C07J 41/0061 (2013.01); C07J 43/003 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0176531 A2 20011018; WO 0176531 A3 20020214; AU 2001253226 B2 20060608; AU 2006202213 A1 20060615; AU 5322601 A 20011023; CA 2405151 A1 20011018; EP 1267898 A2 20030102; EP 1267898 A4 20060201; JP 2003530329 A 20031014
DOCDB simple family (application)
US 0111327 W 20010406; AU 2001253226 A 20010406; AU 2006202213 A 20060525; AU 5322601 A 20010406; CA 2405151 A 20010406; EP 01926709 A 20010406; JP 2001574050 A 20010406