EP 1267909 B1 20100728 - METHODS OF BLOCKING TISSUE DESTRUCTION BY AUTOREACTIVE T CELLS
Title (en)
METHODS OF BLOCKING TISSUE DESTRUCTION BY AUTOREACTIVE T CELLS
Title (de)
VERFAHREN ZUR BLOCKIERUNG DER ZERSTÖRUNG VON GEWEBE MITTELS AUTOREAKTIVER T-ZELLEN
Title (fr)
PROCEDES PERMETTANT D'INHIBER LA DESTRUCTION TISSULAIRE INDUITE PAR LES LYMPHOCYTES T AUTOREACTIFS
Publication
Application
Priority
- US 0140390 W 20010329
- US 19281400 P 20000329
Abstract (en)
[origin: WO0172325A9] Methods for blocking autoreactive T cell-initiated destruction of tissues in a mammal are provided. In one embodiment, the method comprises administering a pharmaceutical composition comprising a biologically effective amount of an isolated and purified CD24 polypeptide, or a fusion protein comprising such polypeptide to a mammalian subject who is suspected of having an autoimmune disease. In another embodiment, the method comprises administering a pharmaceutical composition comprising a biologically effective amount of an anti- CD24 antibody or anti- CD24 Fab fragments to the subject. The present invention also relates to isolated and purified CD24 fusion proteins employed in the present methods and to transgenic mice that express the human CD24 protein on their T cells and/or their vascular endothelial cells but do not express murine heat shock antigen on any cells.
IPC 8 full level
A01K 67/027 (2006.01); A61K 38/17 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61P 3/10 (2006.01); A61P 17/06 (2006.01); A61P 25/00 (2006.01); A61P 29/00 (2006.01); A61P 37/02 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); C07K 4/12 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 5/07 (2010.01); C12N 5/0783 (2010.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/08 (2006.01); A61K 38/095 (2019.01)
CPC (source: EP)
A61K 39/0008 (2013.01); A61P 3/10 (2018.01); A61P 17/06 (2018.01); A61P 25/00 (2018.01); A61P 29/00 (2018.01); A61P 37/02 (2018.01); A61P 37/06 (2018.01); A61P 37/08 (2018.01); C07K 14/70596 (2013.01); C07K 16/2896 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0172325 A1 20011004; WO 0172325 A9 20030220; AT E475428 T1 20100815; AU 2001259792 B2 20051222; AU 5979201 A 20011008; CA 2404340 A1 20011004; CA 2404340 C 20121016; DE 60142684 D1 20100909; DK 1267909 T3 20101108; EP 1267909 A1 20030102; EP 1267909 A4 20060503; EP 1267909 B1 20100728; JP 2004500110 A 20040108
DOCDB simple family (application)
US 0140390 W 20010329; AT 01933358 T 20010329; AU 2001259792 A 20010329; AU 5979201 A 20010329; CA 2404340 A 20010329; DE 60142684 T 20010329; DK 01933358 T 20010329; EP 01933358 A 20010329; JP 2001570286 A 20010329