EP 1268791 A2 20030102 - BRCA-1 REGULATORS AND METHODS OF USE
Title (en)
BRCA-1 REGULATORS AND METHODS OF USE
Title (de)
BRCA-1 REGULATOREN UND DEREN VERWENDUNGEN
Title (fr)
REGULATEURS DE BRCA-1 ET PROCEDES D'UTILISATION
Publication
Application
Priority
- US 0109559 W 20010323
- US 53605800 A 20000323
Abstract (en)
[origin: WO0170982A2] The invention provides ribozymes and encoding nucleic acids having target recognition sequences that allow the ribozyme to target and cleave BRCA-1 regulators, resulting in upregulation of BRCA-1 in a cell. Also provided are nucleic acids encoding BRCA-1 regulators that contain the target sequences recognized by the ribozymes of the invention. Fragments of these nucleic acid and protein sequences also are provided. Further provided is a method for identifying a gene where the expression level is affected by a BRCA-1 regulator and the identity of several such affected genes. Still further provided is a method of identifying a compound that modulates the activity of a BRCA-1 regulator. Also provided is a method of treating cancer, comprising introducing a ribozyme selectively reactive with an RNA encoding a BRCA-1 regulator into a cancerous cell. The invention further comprises a method of detecting a neoplastic cell in a sample.
IPC 1-7
C12N 15/12; C12N 15/11; C07K 14/47; A61K 31/713; C12Q 1/68; G01N 33/68
IPC 8 full level
A61K 31/7105 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 9/00 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/12 (2006.01); C12Q 1/02 (2006.01); C12Q 1/37 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 31/7088 (2013.01); A61P 35/00 (2017.12); C07K 14/4702 (2013.01); C12N 15/113 (2013.01); G01N 33/57407 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2799/027 (2013.01); G01N 2800/52 (2013.01)
Citation (search report)
See references of WO 0170982A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0170982 A2 20010927; WO 0170982 A3 20020822; AU 5098001 A 20011003; CA 2402834 A1 20010927; EP 1268791 A2 20030102; JP 2003527860 A 20030924
DOCDB simple family (application)
US 0109559 W 20010323; AU 5098001 A 20010323; CA 2402834 A 20010323; EP 01924317 A 20010323; JP 2001569365 A 20010323