Global Patent Index - EP 1268832 A4

EP 1268832 A4 20030402 - PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTIDS

Title (en)

PRODUCTION OF ANTIBODIES IN TRANSGENIC PLASTIDS

Title (de)

HERSTELLUNG VON ANTIKÖRPERN IN TRANSGENEN PLASTIDEN

Title (fr)

PRODUCTION D'ANTICORPS DANS DES PLASTES TRANSGENIQUES

Publication

EP 1268832 A4 20030402 (EN)

Application

EP 01918262 A 20010228

Priority

  • US 0106274 W 20010228
  • US 18566100 P 20000229

Abstract (en)

[origin: WO0164929A1] This invention provides compositions and methods for the transformation of plastids of plant cells with multiple genes, and proper association or assembly of multimeric proteins that are heterologous to the plastids of plant cells. A plasmid construct encoding all of the individual polypeptide components of the multimeric protein is provided. Stable integration of the heterologous coding sequences into the plastid genome of the target plant is accomplished through homologous recombination. The present invention achieves assembly of immunoglobulin heavy and light chains, with covalent bonding between the chains, into immunologically active immunoglobulins in the chloroplast.

IPC 1-7

C12N 15/82; C12N 15/10; C12N 15/13; C12N 5/04; C07K 16/00; A01H 5/10; A01H 5/00; C12P 21/08

IPC 8 full level

C07K 16/00 (2006.01); C07K 16/12 (2006.01); C12N 15/13 (2006.01); C12N 15/82 (2006.01); C12N 15/84 (2006.01); C12P 21/08 (2006.01)

CPC (source: EP)

C07K 16/00 (2013.01); C07K 16/1275 (2013.01); C12N 15/8214 (2013.01); C12N 15/8258 (2013.01); C07K 2317/13 (2013.01); C07K 2317/24 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01)

Citation (search report)

  • [PXPY] WO 0020612 A2 20000413 - NOVARTIS AG [CH], et al
  • [XY] WO 9910513 A1 19990304 - UNIV AUBURN [US], et al
  • [Y] US 5925806 A 19990720 - MCBRIDE KEVIN E [US], et al
  • [Y] US 5576198 A 19961119 - MCBRIDE KEVIN E [US], et al
  • [A] SVAB ET AL: "high-frequency plastid transformation in tobacco by selection for a chimeric aadA gene", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 90, February 1993 (1993-02-01), pages 913 - 917, XP002106110, ISSN: 0027-8424
  • See references of WO 0164929A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0164929 A1 20010907; AU 4535801 A 20010912; CA 2401965 A1 20010907; EP 1268832 A1 20030102; EP 1268832 A4 20030402

DOCDB simple family (application)

US 0106274 W 20010228; AU 4535801 A 20010228; CA 2401965 A 20010228; EP 01918262 A 20010228