EP 1269193 A2 20030102 - A LYSOSOMAL PEPSTATIN-INSENSITIVE PROTEINASE AS BIOMARKER FOR BREAST CANCER
Title (en)
A LYSOSOMAL PEPSTATIN-INSENSITIVE PROTEINASE AS BIOMARKER FOR BREAST CANCER
Title (de)
EINE LYSOSOMALE PEPSTATIN-UNEMPFINDLICHE PROTEINASE ALS BIOMARKER FÜR BRUSTKREBS
Title (fr)
PROTEINASE LYSOSOMIALE INSENSIBLE A LA PEPSTATINE COMME NOUVEAU BIOMARQUEUR POUR DETECTER ET DIAGNOSTIQUER LE CANCER DU SEIN
Publication
Application
Priority
- US 0107393 W 20010308
- US 18886100 P 20000313
Abstract (en)
[origin: WO0169260A2] The present invention describes diagnostic and prognostic assays to detect in vascular and tissue samples the presence and activity of the lysosomal pepstatin-insensitive proteinase, CLN2p, which has been newly found to be associated with breast cancer and serves as a novel biomarker for breast cancer, including primary, non-primary, or metastatic breast tumors, neoplasms and carcinomas. The activity of CLN2p was discovered to be significantly elevated when measured in breast tissue samples from patients with primary breast carcinoma, compared with CLN2p levels in normal sample controls, thereby demonstrating an approximately two- to seventeen-fold higher CLN2p activity in breast tumors. These higher levels of CLN2p activity in breast tumors were positively correlated with several known breast cancer biomarkers, such as cathepsin D, estrogen receptor and progesterone receptor. The present invention thus provides CLN2p as new biomarker for use in the detection, diagnosis and prognosis of breast cancer.
IPC 1-7
G01N 33/574; G01N 33/58; G01N 33/577; G01N 33/543; G01N 33/573; C12Q 1/37
IPC 8 full level
C12Q 1/37 (2006.01); G01N 33/543 (2006.01); G01N 33/573 (2006.01); G01N 33/574 (2006.01)
CPC (source: EP)
C12Q 1/37 (2013.01); G01N 33/57415 (2013.01)
Citation (search report)
See references of WO 0169260A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0169260 A2 20010920; WO 0169260 A3 20020510; AU 4731701 A 20010924; CA 2403373 A1 20010920; EP 1269193 A2 20030102; JP 2003527607 A 20030916
DOCDB simple family (application)
US 0107393 W 20010308; AU 4731701 A 20010308; CA 2403373 A 20010308; EP 01920239 A 20010308; JP 2001568088 A 20010308