EP 1270570 B1 20060531 - AMIDE COMPOUNDS AND USE THEREOF
Title (en)
AMIDE COMPOUNDS AND USE THEREOF
Title (de)
AMID-VERBINDUNG UND DEREN VERWENDUNG
Title (fr)
COMPOSES D'AMIDE ET UTILISATION
Publication
Application
Priority
- JP 0102132 W 20010316
- JP 2000074764 A 20000316
Abstract (en)
[origin: EP1270570A1] The present invention relates to an amide compound of the formula <CHEM> wherein R<1> is a hydrogen and the like, R<2> is a hydrogen and the like, X is SO2 and the like, Y is the formula (III) and the like and a is 2, an isomer thereof or pharmaceutically acceptable salts thereof. The compound of the present invention shows a remarkable and selective Rho kinase inhibitory action, is free of problematic toxicity, shows fine oral absorption and drug kinetics (absorption, distribution, metabolism, excretion and the like of the drug), and shows superior properties (e.g., stability etc.) as a compound. Accordingly, it can be used as a therapeutic drug for various diseases in which Rho kinase is involved.
IPC 8 full level
C07D 409/12 (2006.01); A61K 31/437 (2006.01); A61K 31/55 (2006.01); A61P 9/00 (2006.01); A61P 9/08 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 11/06 (2006.01); A61P 15/06 (2006.01); A61P 15/10 (2006.01); A61P 15/18 (2006.01); A61P 19/00 (2006.01); A61P 19/10 (2006.01); A61P 25/00 (2006.01); A61P 27/02 (2006.01); A61P 27/06 (2006.01); A61P 29/00 (2006.01); A61P 31/00 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 37/06 (2006.01); C07D 213/75 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 471/04 (2006.01)
CPC (source: EP KR US)
A61P 9/00 (2018.01 - EP); A61P 9/08 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 9/12 (2018.01 - EP); A61P 11/00 (2018.01 - EP); A61P 11/06 (2018.01 - EP); A61P 15/00 (2018.01 - EP); A61P 15/04 (2018.01 - EP); A61P 15/06 (2018.01 - EP); A61P 15/10 (2018.01 - EP); A61P 15/18 (2018.01 - EP); A61P 19/00 (2018.01 - EP); A61P 19/08 (2018.01 - EP); A61P 19/10 (2018.01 - EP); A61P 25/00 (2018.01 - EP); A61P 25/04 (2018.01 - EP); A61P 25/28 (2018.01 - EP); A61P 27/00 (2018.01 - EP); A61P 27/02 (2018.01 - EP); A61P 27/06 (2018.01 - EP); A61P 29/00 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/18 (2018.01 - EP); A61P 35/00 (2018.01 - EP); A61P 35/04 (2018.01 - EP); A61P 37/00 (2018.01 - EP); A61P 37/02 (2018.01 - EP); A61P 37/06 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 213/75 (2013.01 - EP KR US); C07D 405/12 (2013.01 - EP KR US); C07D 409/12 (2013.01 - EP KR US); C07D 471/04 (2013.01 - EP KR US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 1270570 A1 20030102; EP 1270570 A4 20040218; EP 1270570 B1 20060531; AT E327993 T1 20060615; AU 4118301 A 20010924; CA 2403321 A1 20010920; CA 2403321 C 20090714; CN 1198804 C 20050427; CN 1418194 A 20030514; CY 1105575 T1 20100728; DE 60120138 D1 20060706; DE 60120138 T2 20070329; DE 60120138 T8 20071011; DK 1270570 T3 20061002; ES 2266171 T3 20070301; HK 1049837 A1 20030530; HK 1049837 B 20070119; JP 4776136 B2 20110921; KR 100818060 B1 20080331; KR 100818061 B1 20080401; KR 20020081455 A 20021026; KR 20070087087 A 20070827; PT 1270570 E 20061031; SI 1270570 T1 20061031; US 2003158413 A1 20030821; US 6933305 B2 20050823; WO 0168607 A1 20010920
DOCDB simple family (application)
EP 01912460 A 20010316; AT 01912460 T 20010316; AU 4118301 A 20010316; CA 2403321 A 20010316; CN 01806653 A 20010316; CY 061101198 T 20060825; DE 60120138 T 20010316; DK 01912460 T 20010316; ES 01912460 T 20010316; HK 03101951 A 20030317; JP 0102132 W 20010316; JP 2001567702 A 20010316; KR 20027012156 A 20020916; KR 20077016191 A 20070713; PT 01912460 T 20010316; SI 200130601 T 20010316; US 22165502 A 20021021