EP 1272471 B1 20071003 - NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS
Title (en)
NON-STEROIDAL, TETRACYCLIC COMPOUNDS FOR ESTROGEN-RELATED TREATMENTS
Title (de)
NICHT-STEROIDALE TETRACYCLISCHE VERBINDUNGEN FÜR ÖSTROGEN-VERWANDTE BEHANDLUNGEN
Title (fr)
COMPOSES TETRACYCLIQUE NON STEROIDIQUES DESTINES A DES TRAITEMENTS LIES AUX OESTROGENES
Publication
Application
Priority
- EP 01927762 A 20010321
- EP 0103187 W 20010321
- EP 00201103 A 20000327
- EP 00201105 A 20000327
Abstract (en)
[origin: WO0172713A1] The invention provides non-steroidal estrogenic compounds with estrogenic and anti-estrogenic compounds effects for treatment of estrogen-deficiency related disorders, which compounds are having formula (I) wherein, one of R<a> or R<b> is 'R<e>; R<e> and 'R<e> are OH, optionally independently etherified or esterified; X is N or -C(R<1>)-, wherein R<1> is H, halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens; Y is N or -C(R<2>)-, with the proviso that X and Y are not both N, wherein R<2> has the same meaning as defined for R<1>; Z is C(R<3>,'R<3>)- or -C(R<4>,'R<4>)-C(R<5>,`R<5>)-, wherein R<3>, 'R<3>, R<4>, `R<4>, R<5>, and 'R<5>, independently are H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens. These compounds are useful for estrogen-receptor related treatments in view of a desirable profile of activity for estrogen alpha and estrogen beta receptors.
IPC 8 full level
C07D 221/18 (2006.01); A61K 31/047 (2006.01); A61K 31/05 (2006.01); A61K 31/09 (2006.01); A61K 31/473 (2006.01); A61P 5/30 (2006.01); A61P 15/08 (2006.01); A61P 19/10 (2006.01); A61P 35/00 (2006.01); C07C 33/36 (2006.01); C07C 33/38 (2006.01); C07C 33/50 (2006.01); C07C 39/17 (2006.01); C07C 39/23 (2006.01); C07C 39/42 (2006.01); C07C 43/21 (2006.01); C07C 43/215 (2006.01); C07C 43/225 (2006.01); C07C 43/23 (2006.01); C07C 69/017 (2006.01); C07C 69/28 (2006.01)
CPC (source: EP US)
A61P 5/30 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 13/12 (2017.12 - EP); A61P 15/08 (2017.12 - EP); A61P 19/10 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/24 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07C 39/17 (2013.01 - EP US); C07C 43/21 (2013.01 - EP US); C07C 43/225 (2013.01 - EP US); C07C 69/017 (2013.01 - EP US); C07D 221/18 (2013.01 - EP US); C07C 2603/40 (2017.04 - EP US); C07C 2603/42 (2017.04 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0172713 A1 20011004; AT E374752 T1 20071015; AU 5471001 A 20011008; DE 60130748 D1 20071115; DE 60130748 T2 20080717; EP 1272471 A1 20030108; EP 1272471 B1 20071003; ES 2293986 T3 20080401; JP 2003528858 A 20030930; JP 2009292824 A 20091217; PE 20011131 A1 20011112; US 2003144313 A1 20030731; US 6686371 B2 20040203
DOCDB simple family (application)
EP 0103187 W 20010321; AT 01927762 T 20010321; AU 5471001 A 20010321; DE 60130748 T 20010321; EP 01927762 A 20010321; ES 01927762 T 20010321; JP 2001570626 A 20010321; JP 2009178534 A 20090731; PE 2001000283 A 20010326; US 24012902 A 20021202