EP 1272562 A1 20030108 - ENVIRONMENT RESPONSIVE GELLING COPOLYMER

Title (en)

ENVIRONMENT RESPONSIVE GELLING COPOLYMER

Title (de)

UMWELTREAGIERENDES GELCOPOLYMER

Title (fr)

COPOLYMERE GELIFIANT REAGISSANT A L'ENVIRONNEMENT

Publication

EP 1272562 A1 20030108 (EN)

Application

EP 01914873 A 20010315

Priority

CA 0100325 W 20010315
CA 2427543 A 20030502
US 18948900 P 20000315

Abstract (en)

[origin: WO0168768A1] The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n > 1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form <i>in situ</i> implants useful in slow-release formulations of biologically active molecules.

IPC 1-7

C08L 53/00; C08F 297/00; C08G 63/664; C08G 65/32; A61K 9/00; A61K 47/34

IPC 8 full level

A61L 24/06 (2006.01); A61L 27/16 (2006.01); A61L 27/50 (2006.01); A61L 27/52 (2006.01); C08F 297/00 (2006.01); C08L 51/00 (2006.01); C08L 51/08 (2006.01); C08L 53/00 (2006.01)

CPC (source: EP)

A61L 24/06 (2013.01); A61L 27/16 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); C08F 297/00 (2013.01); C08L 51/003 (2013.01); C08L 51/08 (2013.01); C08L 53/00 (2013.01)

Citation (search report)

See references of WO 0168768A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0168768 A1 20010920; AU 4214401 A 20010924; CA 2402546 A1 20010920; CA 2402546 C 20090602; EP 1272562 A1 20030108

DOCDB simple family (application)

CA 0100325 W 20010315; AU 4214401 A 20010315; CA 2402546 A 20010315; EP 01914873 A 20010315