EP 1272622 A1 20030108 - METHOD FOR MODIFICATION OF PROTEINS BY TRANSGLUTAMINASE
Title (en)
METHOD FOR MODIFICATION OF PROTEINS BY TRANSGLUTAMINASE
Title (de)
VERFAHREN ZUR MODIFIZIERUNG VON PROTEINEN DURCH TRANSGLUTAMINASE
Title (fr)
PROCEDE DE MODIFICATION DE PROTEINES PAR LA TRANSGLUTAMINASE
Publication
Application
Priority
- EP 01933849 A 20010417
- EP 0104400 W 20010417
- EP 00201363 A 20000414
Abstract (en)
[origin: EP1146121A1] The invention relates to a method for coupling a peptide or protein bound glutamine residue to a substrate by acyl transfer, catalysed by a transglutaminase activity whereby the substrate is chosen from the group, consisting of lysine-free peptides of at least 2 amino acids, lysine-free proteins, aminosaccharides, saccharides, aminopolysaccharides and alcohols. In particular, the method can be used to confer to a peptide comprising a glutamine residue the capacity to keep its activity upon passing the stomach. Further the use of transglutaminase for epitope masking is described. <IMAGE>
IPC 1-7
IPC 8 full level
C07K 1/107 (2006.01); C07K 5/02 (2006.01); C07K 5/037 (2006.01); C07K 14/00 (2006.01); C07K 14/415 (2006.01); C07K 14/76 (2006.01); C12N 9/10 (2006.01); C12P 13/02 (2006.01); C12P 21/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 1/1075 (2013.01); C07K 1/1077 (2013.01); C07K 5/0215 (2013.01); C07K 14/415 (2013.01); C07K 14/76 (2013.01); C12P 13/02 (2013.01); C12P 21/02 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0179474A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
EP 1146121 A1 20011017; AU 6022001 A 20011030; EP 1272622 A1 20030108; JP 2003530851 A 20031021; WO 0179474 A1 20011025
DOCDB simple family (application)
EP 00201363 A 20000414; AU 6022001 A 20010417; EP 0104400 W 20010417; EP 01933849 A 20010417; JP 2001577458 A 20010417