EP 1274398 A2 20030115 - METHODS FOR THEPREPARATION OF EFFERVESCENT GRANULES
Title (en)
METHODS FOR THEPREPARATION OF EFFERVESCENT GRANULES
Title (de)
HERSTELLUNGSVERFAHREN FÜR BRAUSEGRANULATE
Title (fr)
TECHNIQUES DE PREPARATION DE GRANULES EFFERVESCENTS
Publication
Application
Priority
- EP 0105017 W 20010420
- US 55352800 A 20000420
Abstract (en)
[origin: WO0180822A2] Disclosed here are effervescent granules having a controllable rate of effervescence. In some embodiments, the such granules comprise an acidic agent, an alkaline agent, a pharmacologically active agent, hot-melt extrudable binder capable of forming a eutectic mixture with the acidic agent and, optionally, a plasticizer. The effervescent granules are made by a hot-melt extrusion process. The present invention also provides a thermal heat process for preparing a pharmacologically active agent containing effervescent granule. In certain aspects, the granules contain pharmacologically active agents such as narcotics, antidiarrheal agents, antiviral agents, anxiolytic agents, a cholesterol lowering agent, an alpha adrenergic blocking agent, a phenanthrene derivative. By way of example, some of the narcotics that may be included in the granules and in the process of preparing the granules include, by way of example: phenanthrene derivatives (e.g., morphine sulfate), and morphine derivatives (e.g., hydromorphone hydrochloride).
IPC 1-7
IPC 8 full level
A61K 9/00 (2006.01); A61K 9/20 (2006.01); A61K 9/16 (2006.01); A61K 9/46 (2006.01); A61K 31/485 (2006.01); A61K 31/506 (2006.01); A61K 31/522 (2006.01); A61K 47/46 (2006.01); A61P 25/02 (2006.01); A61P 25/22 (2006.01); A61P 31/12 (2006.01)
CPC (source: EP KR US)
A61K 9/0007 (2013.01 - EP US); A61K 9/0034 (2013.01 - EP US); A61K 9/0056 (2013.01 - EP US); A61K 9/16 (2013.01 - KR); A61K 9/1694 (2013.01 - EP US); A61K 9/2095 (2013.01 - EP US); A61P 25/00 (2018.01 - EP); A61P 25/02 (2018.01 - EP); A61P 25/22 (2018.01 - EP); A61P 31/00 (2018.01 - EP); A61P 31/12 (2018.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated extension state (EPC)
SI
DOCDB simple family (publication)
WO 0180822 A2 20011101; WO 0180822 A3 20020328; AT E410145 T1 20081015; AU 2001254826 B2 20060316; AU 5482601 A 20011107; BG 107193 A 20030630; BG 65877 B1 20100430; CA 2406833 A1 20011101; CA 2406833 C 20090630; CN 100337613 C 20070919; CN 1437462 A 20030820; CZ 20023419 A3 20030514; DE 60136057 D1 20081120; DK 1274398 T3 20090216; EP 1274398 A2 20030115; EP 1274398 B1 20081008; HU 230267 B1 20151130; HU P0300432 A2 20030728; HU P0300432 A3 20050228; IL 152317 A0 20030529; IL 152317 A 20100531; JP 2003531161 A 20031021; JP 5063848 B2 20121031; KR 20030011829 A 20030211; MX PA02010338 A 20031211; NO 20024947 D0 20021015; NO 20024947 L 20021212; NO 333395 B1 20130527; SK 15102002 A3 20030603; SK 287187 B6 20100208; US 6649186 B1 20031118; ZA 200208456 B 20031020
DOCDB simple family (application)
EP 0105017 W 20010420; AT 01927938 T 20010420; AU 2001254826 A 20010420; AU 5482601 A 20010420; BG 10719302 A 20021014; CA 2406833 A 20010420; CN 01811468 A 20010420; CZ 20023419 A 20010420; DE 60136057 T 20010420; DK 01927938 T 20010420; EP 01927938 A 20010420; HU P0300432 A 20010420; IL 15231701 A 20010420; JP 2001577922 A 20010420; KR 20027014142 A 20021021; MX PA02010338 A 20010420; NO 20024947 A 20021015; SK 15102002 A 20010420; US 55352800 A 20000420; ZA 200208456 A 20021018