EP 1274432 A4 20041110 - COMPOSITIONS CONTAINING ITRACONAZOLE WITH IMPROVED BIOAVAILABILITY AND NARROW INTRA- AND INTER-INDIVIDUAL VARIATION OF ITS ABSORPTION
Title (en)
COMPOSITIONS CONTAINING ITRACONAZOLE WITH IMPROVED BIOAVAILABILITY AND NARROW INTRA- AND INTER-INDIVIDUAL VARIATION OF ITS ABSORPTION
Title (de)
ITRACONAZOL ENTHALTENDE ARZNEIFORMEN MIT VERBESSERTER BIOVERFÜGBARKEIT UND GERINGER INTRA- UND INTERINDIVIDUELLER ABSORPTIONSABWEICHUNG
Title (fr)
COMPOSITIONS CONTENANT DE L'ITRACONAZOLE A BIODISPONIBILITE AMELIOREE ET A FAIBLE ECART INTRA-INDIVIDUEL ET INTER-INDIVIDUEL DE SON ABSORPTION
Publication
Application
Priority
- KR 9900854 W 19991231
- KR 19990055802 A 19991208
Abstract (en)
[origin: WO0141765A1] The present invention relates to agent containing itraconazole - with both improved bioavailability, due to higher water-solubility and impressively reduced difference of pH-dependent solubility, and narrow intra- and inter-individual variation of its absorption- and a manufacturing method thereof. Agent containing itraconazole of the present invention consists of itraconazole, water-soluble macromolecule of 10-100 % w/w to itracotazole, solubilizing agent of 0.1-100 % w/w to itraconazole and pharmaceutically allowed additives. Agent containing itraconazole of the present invention minimizes absorption variation by dozing time after food intake as well as is available for adults with hypoacidity, AIDS patients and normal people. In addition, the manufacturing method introduces the elementary process, the spray drying, thereby control of physical properties of particles containing drug is easier and economy/production is improved.
IPC 1-7
IPC 8 full level
A61K 9/06 (2006.01); A61K 9/10 (2006.01); A61K 9/12 (2006.01); A61K 9/14 (2006.01); A61K 9/16 (2006.01); A61K 9/20 (2006.01); A61K 9/30 (2006.01); A61K 9/48 (2006.01); A61K 31/4196 (2006.01); A61K 31/495 (2006.01); A61K 47/14 (2006.01); A61K 47/18 (2006.01); A61K 47/20 (2006.01); A61K 47/30 (2006.01); A61K 47/32 (2006.01); A61K 47/34 (2006.01); A61K 47/38 (2006.01); A61P 31/10 (2006.01)
CPC (source: EP KR)
A61K 9/1635 (2013.01 - EP); A61K 9/1641 (2013.01 - EP); A61K 9/1652 (2013.01 - EP); A61K 31/495 (2013.01 - EP KR); A61P 31/10 (2017.12 - EP); A61K 9/1611 (2013.01 - EP); A61K 9/1617 (2013.01 - EP)
Citation (search report)
- [E] WO 0030616 A1 20000602 - RTP PHARMA INC [US]
- See references of WO 0141765A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0141765 A1 20010614; AU 1896400 A 20010618; CA 2393737 A1 20010614; CN 1398184 A 20030219; EP 1274432 A1 20030115; EP 1274432 A4 20041110; JP 2003516354 A 20030513; KR 100694667 B1 20070314; KR 20010054823 A 20010702
DOCDB simple family (application)
KR 9900854 W 19991231; AU 1896400 A 19991231; CA 2393737 A 19991231; CN 99817076 A 19991231; EP 99962555 A 19991231; JP 2001543110 A 19991231; KR 19990055802 A 19991208