EP 1274679 A1 20030115 - BIFUNCTIONAL INHIBITORS OF MALARIAL PROTEASES AND USES THEREOF
Title (en)
BIFUNCTIONAL INHIBITORS OF MALARIAL PROTEASES AND USES THEREOF
Title (de)
BIFUNKTIONELLE MALARIA-PROTEASE-INHIBITOREN UND IHRE ANWENDUNG
Title (fr)
INHIBITEURS BIFONCTIONNELS DE PROTEASES PALUDEENNES ET LEURS APPLICATIONS
Publication
Application
Priority
- US 0112000 W 20010412
- US 19902300 P 20000421
Abstract (en)
[origin: WO0183433A1] One aspect of the present invention is a novel class of compounds that are bifunctional inhibitors of aspartic proteases and cysteine proteases, particularly of the malarial proteases, falcipain and the plasmepsins. By inhibiting these proteases the compounds interfere with a function necessary for the growth and survival of the parasite, namely the degradation of hemoglobin. The compounds are useful for the treatment of parasitic infection, specifically malaria. The invention also includes pharmaceutical compositions containing the inventive compounds. In addition, the invention includes methods of treating and/or preventing parasitic infection, particularly malaria, by administering the inventive compounds either alone or in combination with a variety of other antiparasitic agents, vaccines, etc.
IPC 1-7
IPC 8 full level
C07C 317/28 (2006.01); C07D 295/26 (2006.01)
CPC (source: EP)
C07C 317/28 (2013.01); C07D 295/26 (2013.01); Y02A 50/30 (2017.12)
Citation (search report)
See references of WO 0183433A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0183433 A1 20011108; AU 5158701 A 20011112; EP 1274679 A1 20030115
DOCDB simple family (application)
US 0112000 W 20010412; AU 5158701 A 20010412; EP 01924983 A 20010412