EP 1274859 A1 20030115 - SPECIFIC PEPTIDE SUBSTRATE FOR HUMAN YAK1, YAK3A, AND YAK3B AND YEAST YAK1 PROTEIN KINASES
Title (en)
SPECIFIC PEPTIDE SUBSTRATE FOR HUMAN YAK1, YAK3A, AND YAK3B AND YEAST YAK1 PROTEIN KINASES
Title (de)
SPEZIFISCHES PEPTIDSUBSTRAT FÜR MENSCHLICHE YAK1, YAK3A UND YAK3B, SOWIE YAK1 PROTEINKINASE AUS HEVE
Title (fr)
SUBSTRAT PEPTIDIQUE SPECIFIQUE DES PROTEINES KINASES HUMAINES YAK1, YAK3A, ET YAK3B, ET DE LA PROTEINE KINASE YAK1 DE LA LEVURE
Publication
Application
Priority
- US 0030542 W 20001106
- US 16390199 P 19991105
- US 70642600 A 20001103
Abstract (en)
[origin: WO0132918A1] hYAK1, hYAK3a and 3b, and yeast YAK1 polypeptides and polynucleotides, methods for producing such polypeptides by recombinant techniques, and methods of using Ser-164 and these polypeptides and polynucleotides to determine the effect on phosphorylation are disclosed. Also disclosed are methods for utilizing hYAK1, hYAK3a and 3b, and yeast YAK1 polypeptides and polynucleotides in the design of protocols for the treatment of bone loss including osteoporosis; inflammatory diseases such as Adult Respiratory Disease Syndrome (ARDS), Rheumatoid arthritis, Osteoarthritis, Inflammatory Bowel Disease (IBD), psoriasis, dermatitis, asthma, allergies; infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; HIV-associated cachexia and other immunodeficiency disorders; septic shock; pain; injury; cancers; anorexia; bulimia; Parkinson's disease; cardiovascular disease including restenosis, atherosclerosis, acute heart failure, myocardial infarction; hypotension; hypertension; urinary retention; angina pectoris; ulcers; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles de la Tourett's syndrome, among others, and diagnostic assays for such conditions.
IPC 1-7
IPC 8 full level
C07K 14/47 (2006.01); C12N 9/12 (2006.01); C12N 15/54 (2006.01)
CPC (source: EP)
C07K 14/4713 (2013.01); C12N 9/1205 (2013.01); C12Y 207/01037 (2013.01)
Citation (search report)
See references of WO 0132918A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
DOCDB simple family (application)
US 0030542 W 20001106; EP 00976987 A 20001106