Global Patent Index - EP 1274862 A4

EP 1274862 A4 20050622 - CONTROL OF A GENE INDUCED BY OXIDIZED LIPIDS IN HUMAN ARTERY WALL CELLS

Title (en)

CONTROL OF A GENE INDUCED BY OXIDIZED LIPIDS IN HUMAN ARTERY WALL CELLS

Title (de)

REGULATION EINES GENS WELCHES DURCH OXIDIERTE LIPIDE IN MENSCHLICHEN ARTERIEN WANDZELLEN INDUZIERT WIRD

Title (fr)

REGULATION D'UN GENE INDUIT PAR DES LIPIDES OXYDES DANS DES CELLULES HUMAINES DE PAROI ARTERIELLE

Publication

EP 1274862 A4 20050622 (EN)

Application

EP 01923022 A 20010329

Priority

  • US 0110590 W 20010329
  • US 53956900 A 20000331
  • US 54146800 A 20000331

Abstract (en)

[origin: WO0175170A1] This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids <i>(e.g.</i> lipids present in LDLs) and can also repair (reduce) already oxidized lipids and thereby reduce the inflammatory response associated with and characteristic of atherosclerotic plaque formation. Moreover it was a discovery of the invention that individuals vary in the ability of their HDL to afford such protection. Thus an assay of HDL protective and/or repair activity provides a highly effective assay for risk of atherosclerosis and its associated pathologies and such assays are provided herein.

IPC 1-7

C12Q 1/68; G01N 33/53; C07H 21/02; C07H 21/04; A61K 48/00

IPC 8 full level

G01N 27/62 (2006.01); A61K 31/7088 (2006.01); A61K 38/43 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); C12Q 1/26 (2006.01); C12Q 1/42 (2006.01); C12Q 1/68 (2006.01); G01N 21/78 (2006.01); G01N 30/88 (2006.01); G01N 33/15 (2006.01); G01N 33/48 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); G01N 33/573 (2006.01); G01N 33/58 (2006.01); G01N 33/92 (2006.01)

CPC (source: EP)

A61P 3/06 (2017.12); A61P 9/10 (2017.12); A61P 19/02 (2017.12); A61P 29/00 (2017.12); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12Q 1/42 (2013.01); G01N 33/573 (2013.01); G01N 33/92 (2013.01); A61K 48/00 (2013.01); C12Q 1/6883 (2013.01); G01N 2500/10 (2013.01); G01N 2800/044 (2013.01)

Citation (search report)

  • [XY] WO 9820897 A1 19980522 - HARVARD COLLEGE [US]
  • [XY] DUFF JENNIFER L ET AL: "Mitogen-activated protein (MAP) kinase is regulated by the MAP kinase phosphatase (MKP-1) in vascular smooth muscle cells: Effect of actinomycin D and antisense oligonucleotides", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 13, 1995, pages 7161 - 7166, XP002325494, ISSN: 0021-9258
  • [X] METZLER B ET AL: "Induction of mitogen-activated protein kinase phosphatase-1 by arachidonic acid in vascular smooth muscle cells.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 11 DEC 1998, vol. 273, no. 50, 11 December 1998 (1998-12-11), pages 33320 - 33326, XP002325495, ISSN: 0021-9258
  • [Y] SUBBANAGOUNDER ET AL.: "EVIDENCE THAT PHOSPHOLIPID OXIDATION PRODUCTS AND/OR PLATELET-ACTIVATING FACTOR PLAY AN IMPORTANT ROLE IN EARLY ATHEROGENESIS IN VITRO AND IN VIVO INHIBITION BY WEB 2086", CIRCULATION RESEARCH, GRUNE AND STRATTON, BALTIMORE, US, no. 85, 20 August 1999 (1999-08-20), pages 311 - 318, XP002951988, ISSN: 0009-7330
  • [A] HUANG Y ET AL: "Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages.", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. JUL 1999, vol. 19, no. 7, July 1999 (1999-07-01), pages 1600 - 1607, XP002325496, ISSN: 1079-5642
  • [A] LAI K ET AL: "MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-1 IN RAT ARTERIAL SMOOTH MUSCLE CELL PROLIFERATION", JOURNAL OF CLINICAL INVESTIGATION, NEW YORK, NY, US, vol. 98, no. 7, October 1996 (1996-10-01), pages 1560 - 1567, XP002058893, ISSN: 0021-9738
  • [T] REDDY SRINIVASA ET AL: "Mitogen-activated protein kinase phosphatase 1 activity is necessary for oxidized phospholipids to induce monocyte chemotactic activity in human aortic endothelial cells", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 20, 18 May 2001 (2001-05-18), pages 17030 - 17035, XP002325497, ISSN: 0021-9258
  • See references of WO 0175168A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0175170 A1 20011011; AT E306563 T1 20051015; AU 2001249762 B2 20060330; AU 4976101 A 20011015; AU 4976201 A 20011015; CA 2404000 A1 20011011; CA 2404000 C 20100727; CA 2404350 A1 20011011; DE 60113976 D1 20060223; DE 60113976 T2 20060727; DK 1272666 T3 20060227; EP 1272666 A1 20030108; EP 1272666 A4 20040922; EP 1272666 B1 20051012; EP 1274862 A1 20030115; EP 1274862 A4 20050622; EP 1650312 A2 20060426; EP 1650312 A3 20060517; ES 2250378 T3 20060416; JP 2003529375 A 20031007; JP 2003529775 A 20031007; JP 4675539 B2 20110427; WO 0175168 A1 20011011

DOCDB simple family (application)

US 0110592 W 20010329; AT 01923023 T 20010329; AU 2001249762 A 20010329; AU 4976101 A 20010329; AU 4976201 A 20010329; CA 2404000 A 20010329; CA 2404350 A 20010329; DE 60113976 T 20010329; DK 01923023 T 20010329; EP 01923022 A 20010329; EP 01923023 A 20010329; EP 05022081 A 20010329; ES 01923023 T 20010329; JP 2001573040 A 20010329; JP 2001573042 A 20010329; US 0110590 W 20010329