EP 1275644 A1 20030115 - Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
Title (en)
Benzenesulfonamide derivatives, process for their preparation and pharmaceutical compositions containing them
Title (de)
Benzenesulfonamid-derivate, Verfahren zu deren Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
Title (fr)
Nouveaux dérivés de benzène sulfonamide, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
Publication
Application
Priority
FR 0109338 A 20010713
Abstract (en)
Indolyl benzene sulfonamide derivatives (I), their enantiomers, diastereoisomers and salts with acids or bases, are new. <??>Indolyl benzene sulfonamide derivatives (I), their enantiomers, diastereoisomers and salts with acids or bases are new; <??>Ra = OH, alkoxy, aryloxy (optionally substituted), arylalkyloxy (optionally substituted), amino, alkylamino, dialkylamino, arylamino (optionally substituted), or arylalkylamino (optionally substituted); <??>A = CH, N; <??>R<1>-A- = O or R<3>R<4>C=C; <??>R<2> = H or alkyl; <??>Rb, Rc = H, halogen, alkyl, alkoxy, OH or trihaloalkyl; <??>R<3>, R<4> = H, aryl (optionally substituted), alkyl, or heteroaryl (optionally substituted); <??>n = 2-6; <??>m, p = 0-6. <??>With the proviso that: <??>(1) when A = CH, R<1> = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl (optionally substituted), arylcarbonyl (optionally substituted), arylcarbonylalkyl (optionally substituted), aryloxy (optionally substituted), aryloxyalkyl (optionally substituted), arylthio (optionally substituted), arylthioalkyl (optionally substituted), arylamino (optionally substituted), arylalkylamino (optionally substituted), heteroaryl (optionally substituted), heteroarylalkyl (optionally substituted), heteroarylcarbonyl (optionally substituted), heteroarylcarbonylalkyl (optionally substituted), heteroaryloxy (optionally substituted), heteroaryloxyalkyl (optionally substituted), heteroarylthio (optionally substituted), heteroarylthioalkyl (optionally substituted), heteroarylamino (optionally substituted), or heteroalkylamino (optionally substituted); and <??>(2) when A = N, R<1> = H, alkyl, cycloalkyl, cycloalkylalkyl, aryl (optionally substituted), arylcarbonyl (optionally substituted), arylcarbonylalkyl (optionally substituted), arylsulfonyl (optionally substituted), aryloxyalkyl (optionally substituted), arylthioalkyl (optionally substituted), heteroaryl (optionally substituted), heteroarylalkyl (optionally substituted), heteroarylcarbonyl (optionally substituted), heteroarylcarbonylalkyl (optionally substituted), heteroaryloxyalkyl (optionally substituted), heteroarylsulfonylalkyl (optionally substituted), or heteroarylthioalkyl (optionally substituted). <??>Alkyl and alkoxy groups have 1-6 C atoms, trihaloalkyl groups have 1-3C atoms and 1-3 halogens that may be the same or different, cycloalkyl groups have 3-8 C atoms, aryl denotes phenyl or naphthyl, heteroaryl groups may be mono- or bicyclic having 5-11 members with at least one aromatic ring and 1-5 heteroatoms (O, N, S), and if there is a non-aromatic ring in such heterocyclic systems this may contain carbonyl in the ring, substituted groups may be substituted by one or two groups selected from halogens, alkyl, alkoxy, hydroxy, cyano, nitro, amino, alkylamino, dialkylamino, COOH, CONH2, and COO-alkyl. <??>An Independent claim is also included for the preparation of (I).
Abstract (fr)
Composé de formule (I) : <IMAGE> dans laquelle : <IMAGE> Ra représente un groupement hydroxy, alkoxy, aryloxy ou arylalkyloxy, A représente un groupement CH ou un atome d'azote et dans ce cas R<1> est tel que définit dans la description, ou R<1>-A représente ensemble un atome d'oxygène ou un groupement <IMAGE> dans lequel R<3>, R<4> sont tels que définis dans la description, R<2> étant un atome d'hydrogène ou un groupement alkyle, Rb, Rc, identiques ou différents, représentent un atome d'hydrogène, un atome d'halogène, un groupement alkyle, un groupement alkoxy, un groupement hydroxy ou un groupement trihalogénoalkyle, n est un entier compris inclusivement entre 2 et 6, m et p sont des entiers compris inclusivement entre 0 et 6
IPC 1-7
C07D 209/14; C07D 417/12; C07D 401/06; C07D 413/14; C07D 417/14; C07D 409/14; A61K 31/405; A61P 9/00
IPC 8 full level
C07D 403/12 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61P 7/02 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 9/14 (2006.01); A61P 11/06 (2006.01); A61P 11/08 (2006.01); A61P 25/06 (2006.01); C07D 209/14 (2006.01); C07D 209/16 (2006.01); C07D 401/06 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 209/00 (2006.01); C07D 211/00 (2006.01); C07D 261/20 (2006.01); C07D 275/04 (2006.01); C07D 333/50 (2006.01)
CPC (source: EP KR US)
A61P 7/02 (2017.12 - EP); A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 9/14 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 11/08 (2017.12 - EP); A61P 25/06 (2017.12 - EP); C07D 209/14 (2013.01 - EP US); C07D 401/06 (2013.01 - EP US); C07D 403/12 (2013.01 - KR); C07D 409/14 (2013.01 - EP US); C07D 413/14 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US); C07D 417/14 (2013.01 - EP US)
Citation (search report)
- [DA] WO 9506046 A1 19950302 - PFIZER LTD [GB], et al
- [A] EP 0751126 A1 19970102 - TORAY INDUSTRIES [JP]
Designated contracting state (EPC)
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
DOCDB simple family (publication)
EP 1275644 A1 20030115; AR 036340 A1 20040901; AU 2002300093 B2 20070712; BR 0202674 A 20030506; CA 2394037 A1 20030113; CA 2394037 C 20080429; CN 1168715 C 20040929; CN 1397550 A 20030219; EA 005403 B1 20050224; EA 200200665 A1 20030227; FR 2827287 A1 20030117; FR 2827287 B1 20031031; HK 1050681 A1 20030704; HU 0202286 D0 20020928; HU P0202286 A2 20030828; JP 2003064055 A 20030305; JP 4138382 B2 20080827; KR 100498864 B1 20050704; KR 20030007173 A 20030123; MX PA02006852 A 20050725; NO 20023389 D0 20020712; NO 20023389 L 20030114; NO 323868 B1 20070716; NZ 520140 A 20030926; PL 354948 A1 20030127; US 2003109533 A1 20030612; US 6589956 B2 20030708; ZA 200205598 B 20030327
DOCDB simple family (application)
EP 02291746 A 20020711; AR P020102608 A 20020712; AU 2002300093 A 20020712; BR 0202674 A 20020710; CA 2394037 A 20020715; CN 02124161 A 20020715; EA 200200665 A 20020712; FR 0109338 A 20010713; HK 03102798 A 20030417; HU P0202286 A 20020712; JP 2002200910 A 20020710; KR 20020040945 A 20020713; MX PA02006852 A 20020711; NO 20023389 A 20020712; NZ 52014002 A 20020712; PL 35494802 A 20020708; US 19503102 A 20020712; ZA 200205598 A 20020712