EP 1276500 B1 20110608 - BLOCKING LEUKOCYTE EMIGRATION AND INFLAMMATION BY INTERFERING WITH CD99/HEC2
Title (en)
BLOCKING LEUKOCYTE EMIGRATION AND INFLAMMATION BY INTERFERING WITH CD99/HEC2
Title (de)
BLOCKIEREN DER LEUKOZYTENEMIGRATION UND ENTZÜNDUNG DURCH STÖRUNG MIT CD99/HEC2
Title (fr)
INHIBITION DE LA MIGRATION DES LEUCOCYTES ET D'UNE INFLAMMATION PAR PERTURBATION DE CD99/HEC2
Publication
Application
Priority
- US 0107963 W 20010313
- US 18880400 P 20000313
Abstract (en)
[origin: WO0168131A1] The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates to the discovery that CD99 mediates TEM, because blocking CD99 on either endothelial cells or monocytes bloks migration 80-90 %. In conjunction with PECAM inhibitors, TEM blockade approaches 100 %. CD99 is involved in a step in TEM that is distal to the step controlled by PECAM.
IPC 8 full level
A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/28 (2006.01); C12N 15/85 (2006.01); G01N 33/50 (2006.01); G01N 33/567 (2006.01); A61K 48/00 (2006.01)
CPC (source: EP US)
A01K 67/0276 (2013.01 - EP US); A61K 38/177 (2013.01 - EP US); C07K 16/2803 (2013.01 - EP US); C07K 16/2845 (2013.01 - EP US); C07K 16/2896 (2013.01 - EP US); C12N 15/8509 (2013.01 - EP US); G01N 33/5047 (2013.01 - EP US); A01K 2217/05 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); A01K 2267/0368 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); A61K 2039/505 (2013.01 - EP US); C07K 2317/76 (2013.01 - EP US); C07K 2319/30 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0168131 A1 20010920; AT E511856 T1 20110615; CA 2402530 A1 20010920; CA 2402530 C 20140114; EP 1276500 A1 20030122; EP 1276500 A4 20030409; EP 1276500 B1 20110608; ES 2368419 T3 20111117; US 2003211099 A1 20031113; US 2007154450 A1 20070705; US 7223395 B2 20070529
DOCDB simple family (application)
US 0107963 W 20010313; AT 01920325 T 20010313; CA 2402530 A 20010313; EP 01920325 A 20010313; ES 01920325 T 20010313; US 22175803 A 20030327; US 67968307 A 20070227