EP 1276730 A2 20030122 - THIAZOLIDINEDIONE ANALOGUES AND THEIR USE FOR THE TREATMENT OF DIABETES
Title (en)
THIAZOLIDINEDIONE ANALOGUES AND THEIR USE FOR THE TREATMENT OF DIABETES
Title (de)
THIAZOLIDINDION-ANALOGA UND IHRE VERWENDUNG ZUR BEHANDLUNG VON DIABETES
Title (fr)
COMPOSITIONS ET METHODES DESTINEES AU TRAITEMENT DU DIABETE, DE L'HYPERLIPIDEMIE, DE L'HYPERCHOLESTEROLEMIE ET DE L'ATHEROSCLEROSE
Publication
Application
Priority
- US 0113131 W 20010424
- US 19914600 P 20000424
- US 28198201 P 20010406
Abstract (en)
[origin: WO0181328A2] The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.
IPC 1-7
C07D 277/34; C07D 417/12; C07D 417/14; C07J 3/00; A61K 31/426; A61K 31/427; A61K 31/4439; A61K 31/497; A61K 31/56; A61P 3/10
IPC 8 full level
A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/569 (2006.01); A61P 3/06 (2006.01); A61P 3/10 (2006.01); A61P 9/10 (2006.01); C07D 261/12 (2006.01); C07D 277/20 (2006.01); C07D 277/34 (2006.01); C07D 311/70 (2006.01); C07D 413/04 (2006.01); C07D 413/12 (2006.01); C07D 417/04 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07J 3/00 (2006.01)
CPC (source: EP)
A61P 3/06 (2017.12); A61P 3/10 (2017.12); A61P 9/10 (2017.12); C07D 261/12 (2013.01); C07D 277/20 (2013.01); C07D 277/34 (2013.01); C07D 311/70 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 417/04 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C07J 3/00 (2013.01)
Citation (search report)
See references of WO 0181328A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0181328 A2 20011101; WO 0181328 A3 20020221; AU 5913001 A 20011107; CA 2402123 A1 20011101; EP 1276730 A2 20030122; JP 2003531200 A 20031021
DOCDB simple family (application)
US 0113131 W 20010424; AU 5913001 A 20010424; CA 2402123 A 20010424; EP 01932617 A 20010424; JP 2001578420 A 20010424