EP 1276740 A2 20030122 - NOVEL EPOTHILONE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND THEIR PHARMACEUTICAL USE
Title (en)
NOVEL EPOTHILONE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND THEIR PHARMACEUTICAL USE
Title (de)
NEUE EPOTHILON-DERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND IHRE PHARMAZEUTISCHE VERWENDUNG
Title (fr)
NOUVEAUX DERIVES D'EPOTHILONE, PROCEDE PERMETTANT DE LES PREPARER ET LEUR UTILISATION PHARMACEUTIQUE
Publication
Application
Priority
- DE 10020517 A 20000419
- EP 0104552 W 20010419
Abstract (en)
[origin: WO0181342A2] The invention relates to novel epothilone derivatives of general formula (I), wherein R<5> represents a halogen atom or a cyano group and the other substituents have the meanings as cited in the description. The novel compounds interact with tubulin by stabilizing formed microtubules. They are capable of influencing the cell division in a phase-specific manner and are well-suited for the treatment of malignant tumors, for example, ovarian, stomach, colon, adeno, breast, lung, head and neck carcinomas, malignant melanoma, acute lymphocytic and myelocytic leukemia. In addition, they are well-suited for anti-angiogenesis therapy and for the treatment of chronic inflammable medical disorders (psoriasis, arthritis). In order to prevent uncontrolled cell growths as well as to improve the compatibility of medical implants, the inventive epothilone derivatives can be applied to or introduced into polymeric materials. The inventive compounds can be used alone or in order to obtain additive or synergistic effects, in conjunction with additional principles and substance classes that can be used in tumor therapy.
IPC 1-7
C07D 419/06; C07D 413/06; A61K 31/44; A61K 31/42; A61K 31/425; A61P 35/00
IPC 8 full level
A61K 31/427 (2006.01); A61P 17/06 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 35/02 (2006.01); A61P 43/00 (2006.01); C07D 401/06 (2006.01); C07D 405/06 (2006.01); C07D 413/04 (2006.01); C07D 413/06 (2006.01); C07D 417/04 (2006.01); C07D 417/06 (2006.01); C07D 491/04 (2006.01); C07D 493/04 (2006.01); C07D 493/10 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP US)
A61P 17/06 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); A61P 35/02 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 401/06 (2013.01 - EP US); C07D 405/06 (2013.01 - EP US); C07D 413/04 (2013.01 - EP US); C07D 413/06 (2013.01 - EP US); C07D 417/04 (2013.01 - EP US); C07D 417/06 (2013.01 - EP US); C07D 491/04 (2013.01 - EP US); C07D 493/04 (2013.01 - EP US); C07D 493/10 (2013.01 - EP US); Y02P 20/55 (2015.11 - EP US)
Citation (search report)
See references of WO 0181342A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0181342 A2 20011101; WO 0181342 A3 20020510; AU 6222101 A 20011107; DE 10020517 A1 20011025; EP 1276740 A2 20030122; JP 2003531207 A 20031021; NO 20025029 D0 20021018; NO 20025029 L 20021018; US 2004058969 A1 20040325
DOCDB simple family (application)
EP 0104552 W 20010419; AU 6222101 A 20010419; DE 10020517 A 20000419; EP 01936262 A 20010419; JP 2001578432 A 20010419; NO 20025029 A 20021018; US 25792502 A 20021018