EP 1278502 A4 20030521 - PROTEASE INHIBITORS

Title (en)

PROTEASE INHIBITORS

Title (de)

PROTEASE INHIBITOREN

Title (fr)

INHIBITEURS A PROTEASE

Publication

EP 1278502 A4 20030521 (EN)

Application

EP 01970508 A 20010417

Priority

US 0112326 W 20010417
US 19849300 P 20000418
US 27381101 P 20010307

Abstract (en)

[origin: WO0189451A2] The present invention provides methods which use 4-amino-azepan-3-one protease inhibitors of cathepsin S in the treatment of diseases in which cathepsin S is implicated, especially treatment or prevention of autoimmune disease; treatment or prevention of a disease state caused by the formation of atherosclerotic lesions and complications arising therefrom; and diseases requiring inhibition, for therapy, of a class II MHC-restricted immune response, inhibition of an asthmatic response, inhibition of an allergic response, inhibition of immune response against a transplanted organ or tissue, or inhibition of elastase activity in atheroma, and novel compounds for use therewith.

IPC 1-7

A61K 31/55; A61P 37/00; A61P 19/02; C07D 421/14; C07D 223/08; C07D 401/12; C07D 405/12; C07D 405/14; C07D 409/12; C07D 409/14; C07D 417/14; C07D 491/04

IPC 8 full level

C07D 491/048 (2006.01); A61K 31/55 (2006.01); A61P 1/04 (2006.01); A61P 1/16 (2006.01); A61P 3/10 (2006.01); A61P 5/14 (2006.01); A61P 7/00 (2006.01); A61P 7/04 (2006.01); A61P 7/06 (2006.01); A61P 9/10 (2006.01); A61P 11/06 (2006.01); A61P 17/00 (2006.01); A61P 17/02 (2006.01); A61P 19/02 (2006.01); A61P 19/04 (2006.01); A61P 21/04 (2006.01); A61P 25/28 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 37/06 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07D 223/08 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 409/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 421/14 (2006.01); C07D 491/04 (2006.01); C07D 495/04 (2006.01)

CPC (source: EP KR)

A61K 31/55 (2013.01 - KR); A61P 1/04 (2017.12 - EP); A61P 1/16 (2017.12 - EP); A61P 3/10 (2017.12 - EP); A61P 5/14 (2017.12 - EP); A61P 7/00 (2017.12 - EP); A61P 7/04 (2017.12 - EP); A61P 7/06 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 11/06 (2017.12 - EP); A61P 17/00 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 19/02 (2017.12 - EP); A61P 19/04 (2017.12 - EP); A61P 21/04 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 27/02 (2017.12 - EP); A61P 29/00 (2017.12 - EP); A61P 37/00 (2017.12 - EP); A61P 37/06 (2017.12 - EP); A61P 37/08 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 223/08 (2013.01 - EP); C07D 401/12 (2013.01 - EP); C07D 405/12 (2013.01 - EP); C07D 405/14 (2013.01 - EP); C07D 409/12 (2013.01 - EP); C07D 409/14 (2013.01 - EP); C07D 417/14 (2013.01 - EP); C07D 421/14 (2013.01 - EP); C07D 491/04 (2013.01 - EP)

Citation (search report)

[E] WO 0217924 A1 20020307 - SMITHKLINE BEECHAM CORP [GB], et al
[E] WO 0170232 A1 20010927 - SMITHKLINE BEECHAM CORP [US], et al
[PX] WO 0038687 A1 20000706 - SMITHKLINE BEECHAM CORP [US], et al
[A] WO 9805336 A1 19980212 - SMITHKLINE BEECHAM CORP [US], et al
[T] KIM W & KANG K: "Recent developments of cathepsin inhibitors and their selectivity", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 12, no. 3, 2002, pages 419 - 432, XP002235404
See references of WO 0189451A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0189451 A2 20011129; WO 0189451 A3 20020404; AR 032319 A1 20031105; AU 9050701 A 20011203; BR 0108954 A 20060509; CA 2406829 A1 20011129; CN 1431904 A 20030723; CO 5280088 A1 20030530; CZ 20023460 A3 20040317; EP 1278502 A2 20030129; EP 1278502 A4 20030521; HK 1053785 A1 20031107; HU P0301781 A2 20030929; IL 151087 A0 20030410; JP 2004526662 A 20040902; KR 20020089482 A 20021129; MX PA02010276 A 20030425; NO 20025005 D0 20021017; NO 20025005 L 20021206; PL 366040 A1 20050124

DOCDB simple family (application)

US 0112326 W 20010417; AR P010101786 A 20010417; AU 9050701 A 20010417; BR 0108954 A 20010417; CA 2406829 A 20010417; CN 01808290 A 20010417; CO 01029287 A 20010416; CZ 20023460 A 20010417; EP 01970508 A 20010417; HK 03104420 A 20030619; HU P0301781 A 20010417; IL 15108701 A 20010417; JP 2001585697 A 20010417; KR 20027013896 A 20021017; MX PA02010276 A 20010417; NO 20025005 A 20021017; PL 36604001 A 20010417