EP 1280899 A2 20030205 - GENE AND SEQUENCE VARIATION ASSOCIATED WITH SENSING CARBOHYDRATE COMPOUNDS AND OTHER SWEETENERS
Title (en)
GENE AND SEQUENCE VARIATION ASSOCIATED WITH SENSING CARBOHYDRATE COMPOUNDS AND OTHER SWEETENERS
Title (de)
GEN UND SEQUENZVARIATION DIE MIT DER DETEKTION VON KOHLENHYDRATEN UND ANDERE SÜSSSTOFFEN ASSOZIERT SIND
Title (fr)
GENE ET VARIATION DE SEQUENCE ASSOCIES A LA PERCEPTION DE COMPOSES D'HYDRATES DE CARBONE ET D'AUTRES PRODUITS SUCRANTS
Publication
Application
Priority
- US 0113387 W 20010425
- US 20079400 P 20000428
- US 22141900 P 20000728
- US 24744300 P 20001110
Abstract (en)
[origin: WO0183749A2] The present invention relates to the discovery of a gene and its sequence variation associated with preference for carbohydrates, other sweet compounds, or ethanol. The present invention also relates to the study of metabolic pathways to identify other genes, receptors, and relationships that contribute to differences in sensing of carbohydrates or ethanol. The present invention also relates to germline or somatic sequence variations and its use in the diagnosis and prognosis of predisposition to diabetes, other obesity related disorders, or ethanol consumption. The present invention also provided probes or primers specific for the detection and analysis of such sequence variation. The present invention also relates to method for screening drugs for inhibition or restoration of gene function as antidiabetic, antiobesity, or antialcohol consumption therapies. The present invention relates to other antidiabetic, antiobesity disorder, or antialcohol consumption therapies, such as gene therapy, protein replacement therapy, etc. Finally, the present invention relates to a method for identifying sweeteners or alcohols utilizing the gene and its variations.
IPC 1-7
C12N 15/12; C07K 14/705; G01N 33/68; C12Q 1/68; C07K 16/28; A61K 38/17; A01K 67/027
IPC 8 full level
A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 25/28 (2006.01); A61P 25/32 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01)
CPC (source: EP)
A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 25/28 (2017.12); A61P 25/32 (2017.12); A61P 43/00 (2017.12); C07K 14/705 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01)
Citation (search report)
See references of WO 0183749A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0183749 A2 20011108; WO 0183749 A3 20020718; AU 5568101 A 20011112; CA 2406999 A1 20011108; EP 1280899 A2 20030205; JP 2003531614 A 20031028
DOCDB simple family (application)
US 0113387 W 20010425; AU 5568101 A 20010425; CA 2406999 A 20010425; EP 01928871 A 20010425; JP 2001580356 A 20010425