EP 1280934 A2 20030205 - IN-SILICO-SCREENING FOR DOCKING ON SUB-DOMAIN IIID OF HCV-IRES
Title (en)
IN-SILICO-SCREENING FOR DOCKING ON SUB-DOMAIN IIID OF HCV-IRES
Title (de)
IN-SILICO SCREENING VERFAHREN FÜR ANLEGEN AN DIE SUB-DOMÄNE IIID DES HCV-IRES
Title (fr)
AJUSTEMENT AU SOUS-DOMAINE IIID DU HCV-IRES PAR CRIBLAGE IN SILICO
Publication
Application
Priority
- GB 0101871 W 20010426
- GB 0010173 A 20000426
- US 19977300 P 20000426
Abstract (en)
[origin: WO0181627A2] A model structure of sub-domain IIId of the hepatitis C virus internal ribosome entry site has been elucidated. The invention provides an <i>in silico</i> method for identifying a compound that interacts with sub-domain IIId, comprising the steps of: a) providing atomic co-ordinates of said sub-domain IIId in a storage medium on a computer; and b) using said computer to apply molecular modelling techniques to said co-ordinates. Suitable methods include <i>de novo</i> compound design, use of a pharmacophore, and automated docking algorithms.
IPC 1-7
IPC 8 full level
G16B 15/30 (2019.01); C12Q 1/68 (2006.01); G01N 33/569 (2006.01)
CPC (source: EP US)
G16B 15/00 (2019.01 - EP); G16B 15/30 (2019.01 - EP US)
Citation (search report)
See references of WO 0181627A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0181627 A2 20011101; WO 0181627 A3 20020411; AU 5053401 A 20011107; EP 1280934 A2 20030205
DOCDB simple family (application)
GB 0101871 W 20010426; AU 5053401 A 20010426; EP 01923850 A 20010426