EP 1286590 A2 20030305 - PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR BETA-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF
Title (en)
PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR BETA-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF
Title (de)
ANALOGA UND MIMETIKA VON PEPTIDEN FÜR DIE IN-VIVO-VERWENDUNG IN DER BEHANDLUNG VON KRANKHEITEN, DIE MIT ABNORMALER PROTEINFALTUNG IN AMYLOID- ODER AMYLOID ÄHNLICHEN ABLAGERUNGEN ODER IHREM AN BETA-FALTBLATTSTRUKTUR REICHEM PATHOLOGISCHEM VORLÄUFER VERBUNDEN SIND
Title (fr)
ANALOGUES ET MIMETIQUES PEPTIDIQUES POUVANT ETRE UTILISES IN VIVO POUR TRAITER DES MALADIES ASSOCIEES AU REPLI ANORMAL PROTEIQUE EN DEPOTS AMYLOIDES OU PSEUDO-AMYLOIDES OU LEUR PRECURSEUR PATHOLOGIQUE RICHE EN BETA-FEUILLE
Publication
Application
Priority
- US 0030416 W 20001104
- US 16391199 P 19991105
Abstract (en)
[origin: WO0134631A2] The present invention is an inhibitory peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The inhibitory peptide is a beta sheet breaker peptide analog designed by chemical modification of beta sheet breaker peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The present invention also includes an inhibitory peptide capable of inhibiting conformational changes in prion PrP protein associated with amyloidosis. The inhibitory peptide being a beta sheet breaker peptide analog designed by chemical modification of a beta sheet breaker peptide capable of inhibiting the conformational changes in prior PrP protein associated with amyloidosis. In addition, the present invention includes a peptide mimetic with the structure PMiA beta 5. In another embodiment, the peptide mimetic has the structure PMiPrP13. In yet another embodiment, the peptide mimetic has the structure PMiPrP5.
[origin: WO0134631A2] The present invention is an inhibitory peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The inhibitory peptide is a beta sheet breaker peptide analog designed by chemical modification of beta sheet breaker peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The present invention also includes an inhibitory peptide capable of inhibiting conformational changes in prion PrP protein associated with amyloidosis. The inhibitory peptide being a beta sheet breaker peptide analog designed by chemical modification of a beta sheet breaker peptide capable of inhibiting the conformational changes in prior PrP protein associated with amyloidosis. In addition, the present invention includes a peptide mimetic with the structure PMiA beta 5. In another embodiment, the peptide mimetic has the structure PMiPrP13. In yet another embodiment, the peptide mimetic has the structure PMiPrP5.
IPC 1-7
IPC 8 full level
A61K 31/20 (2006.01); A61K 38/00 (2006.01); A61P 25/28 (2006.01); C07C 229/28 (2006.01); C07C 229/34 (2006.01); C07K 5/02 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 7/64 (2006.01); C07K 14/47 (2006.01)
CPC (source: EP KR)
A61P 25/28 (2017.12 - EP); C07C 229/34 (2013.01 - EP); C07K 5/0207 (2013.01 - EP); C07K 7/06 (2013.01 - KR); C07K 14/47 (2013.01 - EP); C07K 14/4711 (2013.01 - EP); A61K 38/00 (2013.01 - EP); C07C 2601/08 (2017.04 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0134631 A2 20010517; WO 0134631 A3 20021227; AU 1463501 A 20010606; AU 781044 B2 20050505; BR 0015513 A 20040706; CA 2389041 A1 20010517; CN 1437442 A 20030820; EA 004739 B1 20040826; EA 200200536 A1 20021226; EP 1286590 A2 20030305; EP 1286590 A4 20050511; IL 149392 A0 20021110; JP 2004513873 A 20040513; KR 20020079731 A 20021019; KR 20060133114 A 20061222; MX PA02004468 A 20040910
DOCDB simple family (application)
US 0030416 W 20001104; AU 1463501 A 20001104; BR 0015513 A 20001104; CA 2389041 A 20001104; CN 00819247 A 20001104; EA 200200536 A 20001104; EP 00976928 A 20001104; IL 14939200 A 20001104; JP 2001537342 A 20001104; KR 20027005797 A 20020504; KR 20067025305 A 20061130; MX PA02004468 A 20001104