EP 1287162 A2 20030305 - GENE EXPRESSION PROFILING OF INFLAMMATORY BOWEL DISEASE
Title (en)
GENE EXPRESSION PROFILING OF INFLAMMATORY BOWEL DISEASE
Title (de)
ERMITTLUNG DES GENEXPRESSIONSPROFILS BEI ENTZÜNDLICHEN DARMERKRANKUNGEN
Title (fr)
PROFILAGE DE L'EXPRESSION GENETIQUE D'UNE AFFECTION INTESTINALE INFLAMMATOIRE
Publication
Application
Priority
- US 0041457 W 20001023
- US 16083599 P 19991021
Abstract (en)
[origin: WO0129269A2] The present invention relates to methods for identifying and/or classifying patients with inflammatory bowel diseases (IBD), particularly patients with Crohn's disease or ulcerative colitis. Gene expression profiling shows broad and fundamental differences in the pathogenic mechanism of UC and CD. The subject method is based on the findings that certain genes are differentially expressed in intestinal tissue of IBD patients compared with related normal cells, such as normal colon cells. That change can be used to identify or classify IBD cells by the upregulation and/or downregulation of expression of particular genes, alterations in protein levels or modification, or changes at the genomic level (such as mutation, methylation, etc), e.g., an event which is implicated in the pathology of inflammatory bowel diseases.
IPC 1-7
IPC 8 full level
A61P 43/00 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6883 (2018.01); C12Q 1/6837 (2018.01)
CPC (source: EP)
A61P 43/00 (2017.12); C12Q 1/6883 (2013.01); C12Q 1/6837 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
See references of WO 0129269A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 0129269 A2 20010426; WO 0129269 A3 20021205; AU 2468501 A 20010430; AU 784861 B2 20060706; CA 2356207 A1 20010426; CA 2356207 C 20121009; EP 1287162 A2 20030305; EP 2319939 A2 20110511; EP 2319939 A3 20120926; IL 143936 A0 20020421
DOCDB simple family (application)
US 0041457 W 20001023; AU 2468501 A 20001023; CA 2356207 A 20001023; EP 00988479 A 20001023; EP 10182252 A 20001023; IL 14393600 A 20001023