EP 1287362 A2 20030305 - COMPOSITIONS AND METHODS FOR MODULATING TUMOR SPECIFIC EXPRESSION
Title (en)
COMPOSITIONS AND METHODS FOR MODULATING TUMOR SPECIFIC EXPRESSION
Title (de)
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION TUMORSPEZIFISCHER EXPRESSION
Title (fr)
COMPOSITIONS ET METHODES DESTINEES A LA MODULATION DE L'EXPRESSION SPECIFIQUE DES TUMEURS
Publication
Application
Priority
- US 0116944 W 20010524
- US 20790000 P 20000525
Abstract (en)
[origin: WO0190306A2] The present invention relates to promoters, enhancers and other regulatory elements that direct expression within tumor cells, comprising nucleotide sequences from the 5' regulatory region, and transcriptionally active fragments thereof, that control expression of a renal cell carcinoma related protein, MN-CA9. Specifically provided are expression vectors, host cells and transgenic animals wherein an MN-CA9 regulatory region is capable of controlling expression of a heterologous gene, over-expressing an endogenous gene or an inhibitor of a pathological process or knocking out expression of a specific gene believed to be important in cancer development and/or progression. The invention also relates to methods for using said vectors, cells and animals for screening candidate molecules for agonists and antagonists of cancer development and/or progression. The invention further relates to compositions and methods for modulating expression of compounds within tumor cells, and to screening compounds that modulate expression within tumor cells. Methods for using the molecules and compounds identified by the screening assays for therapeutic treatments also are provided.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/7088 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61K 48/00 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/47 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0190306 A2 20011129; WO 0190306 A3 20020404; AU 6808701 A 20011203; CA 2410094 A1 20011129; CN 1447920 A 20031008; EP 1287362 A2 20030305; EP 1287362 A4 20040512; JP 2004510406 A 20040408
DOCDB simple family (application)
US 0116944 W 20010524; AU 6808701 A 20010524; CA 2410094 A 20010524; CN 01813165 A 20010524; EP 01945989 A 20010524; JP 2001587102 A 20010524