EP 1294406 A2 20030326 - MODULATION OF CHROMOSOME FUNCTION BY CHROMATIN REMODELING AGENTS
Title (en)
MODULATION OF CHROMOSOME FUNCTION BY CHROMATIN REMODELING AGENTS
Title (de)
MODULATION VON CHROMOSOME-FUNKTION DURCH CHROMATINREMODELLIERENDER MITTELN
Title (fr)
MODULATION DE LA FONCTION CHROMOSOMIQUE PAR DES AGENTS REMODELANT LA CHROMATINE
Publication
Application
Priority
- EP 0108097 W 20010626
- US 60364700 A 20000626
Abstract (en)
[origin: WO0200262A2] The present invention concerns a process for modulating the function of a DNA element in a eukaryotic cell, comprising the step of contacting a genomic DNA element, so-called "chromatin responsive element" (CRE), with a compound having a molecular weight of less than approximately 5 KDa, and having the capacity to bind a sequence-specific manner to said CRE, said step of contacting being carried out in conditions permitting chromatin remodeling of the CRE by said compound, wherein said chromatin remodeling of the CRE alters the activity of one or more other DNA elements, so called "modulated DNA elements" in the genome.
IPC 1-7
IPC 8 full level
A01H 5/00 (2006.01); A01K 67/027 (2006.01); A61K 31/7115 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07K 14/47 (2006.01); C09K 11/06 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/68 (2006.01); G01N 33/53 (2006.01); G01N 33/566 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 35/00 (2017.12); A61P 43/00 (2017.12); C07K 14/4702 (2013.01); A01K 2217/05 (2013.01); A61K 38/00 (2013.01); A61K 48/00 (2013.01)
Citation (search report)
See references of WO 0200262A2
Citation (examination)
PARKS M. ET AL: "Optimization of the hairpin polyamide design for recognition of the minor groove of DNA", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, 1996, US, pages 6147 - 6152
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0200262 A2 20020103; WO 0200262 A3 20021031; AU 7974401 A 20020108; CA 2409408 A1 20020103; EP 1294406 A2 20030326; JP 2004501620 A 20040122
DOCDB simple family (application)
EP 0108097 W 20010626; AU 7974401 A 20010626; CA 2409408 A 20010626; EP 01957960 A 20010626; JP 2002505043 A 20010626