EP 1294857 A2 20030326 - GENETICALLY MODIFIED T-CELLS, METHOD FOR PRODUCING THEM AND USE THEREOF
Title (en)
GENETICALLY MODIFIED T-CELLS, METHOD FOR PRODUCING THEM AND USE THEREOF
Title (de)
GEN-MODIFIZIERTE T-ZELLEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG
Title (fr)
LYMPHOCYTES T GENETIQUEMENT MODIFIES, LEUR PROCEDE DE PRODUCTION ET LEUR UTILISATION
Publication
Application
Priority
- DE 0102184 W 20010608
- DE 10028833 A 20000609
Abstract (en)
[origin: WO0194551A2] The invention relates to in-vitro genetically modified T-cells for preventing allogenic transplant rejection in vivo, to methods for producing them and to their use. T-cells of the transplant recipient are stimulated in vitro with cells of the transplant donor or with cells which express dominant MHC molecules and at the same time, transduced with immunomodulating genes by means of gene transfer. After the gene transfer, the transduced T-cells begin to express the immunomodulatory genes. The gene transfer can be carried out using retro viruses, other viral vector systems or liposomes. The conditions selected for the experiment, which result in the generation and expansion of allo-specific T-cells, ensure that the T-cells migrate into the allogenic transplant and into the draining lymph nodes specifically according to the in vivo application and can express the immunomodulating genes there. The invention provides an effective means of preventing the rejection of allogenic transplants (cells, tissues, organs) and is therefore an effective means of inducing and maintaining tolerance of allogenic transplants (cells, tissues, organs) in transplant medicine.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 39/00 (2006.01); A61P 37/02 (2006.01); C12N 5/0783 (2010.01); C12N 5/10 (2006.01); A61K 35/12 (2015.01); A61K 48/00 (2006.01)
CPC (source: EP US)
A61K 39/001 (2013.01 - EP US); A61K 39/4611 (2023.05 - EP US); A61K 39/4621 (2023.05 - EP US); A61K 39/46434 (2023.05 - EP US); A61K 39/464838 (2023.05 - EP US); A61K 2239/38 (2023.05 - US); A61P 37/02 (2018.01 - EP); C12N 5/0636 (2013.01 - EP US); A61K 48/00 (2013.01 - EP US); A61K 2035/122 (2013.01 - EP US); A61K 2239/38 (2023.05 - EP); C12N 2510/00 (2013.01 - EP US)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0194551 A2 20011213; WO 0194551 A3 20020718; CA 2381459 A1 20011213; DE 10128980 A1 20020110; DE 10128980 B4 20051215; EP 1294857 A2 20030326; JP 2004523202 A 20040805; US 2002119571 A1 20020829
DOCDB simple family (application)
DE 0102184 W 20010608; CA 2381459 A 20010608; DE 10128980 A 20010608; EP 01949257 A 20010608; JP 2002502094 A 20010608; US 6891602 A 20020211