Global Patent Index - EP 1294949 A4

EP 1294949 A4 20040825 - HUMAN TUMOR NECROSIS FACTOR DELTA AND EPSILON

Title (en)

HUMAN TUMOR NECROSIS FACTOR DELTA AND EPSILON

Title (de)

MENSCHLICHER TUMORNEKROSEFAKTOR DELTA UND EPSILON

Title (fr)

FACTEUR DE NECROSE TUMORALE HUMAIN DELTA ET EPSILON

Publication

EP 1294949 A4 20040825 (EN)

Application

EP 01961605 A 20010614

Priority

  • US 0119026 W 20010614
  • US 21153700 P 20000615
  • US 24195200 P 20001023
  • US 25487500 P 20001213
  • US 27624801 P 20010316
  • US 27797801 P 20010323
  • US 29349901 P 20010525

Abstract (en)

[origin: WO0196528A2] The invention relates to human TNF delta and TNF epsilon polypeptides, polynucleotides encoding the polypeptides, methods for producing the polypeptides, in particular by expressing the polynucleotides, and agonists and antagonists of the polypeptides. The invention further relates to methods for utilizing such polynucleotides, polypeptides, agonists and antagonists for applications, which relate, in part, to research, diagnostic and clinical arts.

IPC 1-7

A61K 38/00; C07K 14/525; C07K 14/715

IPC 8 full level

A61K 47/48 (2006.01); A61K 49/00 (2006.01); C07K 14/52 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); G01N 33/564 (2006.01)

CPC (source: EP)

A61K 47/6849 (2017.07); A61K 49/0004 (2013.01); C07K 14/52 (2013.01); C07K 14/70575 (2013.01); C07K 16/2875 (2013.01); G01N 33/564 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/622 (2013.01)

Citation (search report)

  • [X] WO 9733902 A1 19970918 - HUMAN GENOME SCIENCES INC [US], et al
  • [X] WO 9900518 A1 19990107 - ABBOTT LAB [US]
  • [X] EP 0911633 A1 19990428 - SMITHKLINE BEECHAM CORP [US]
  • [X] WO 9928462 A2 19990610 - GENENTECH INC [US], et al
  • [X] WO 9950416 A1 19991007 - UPJOHN CO [US], et al
  • [AD] US 5969102 A 19991019 - BRAM RICHARD J [US], et al
  • [X] HAHNE M ET AL: "APRIL, a new ligand of the tumor necrosis factor family, Stimulates tumor cell growth", JOURNAL OF EXPERIMENTAL MEDICINE, TOKYO, JP, vol. 188, 21 September 1998 (1998-09-21), pages 1185 - 1190, XP002093077, ISSN: 0022-1007
  • [X] KELLY KIMBERLY ET AL: "APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death", CANCER RESEARCH, vol. 60, no. 4, 15 February 2000 (2000-02-15), pages 1021 - 1027, XP002285265, ISSN: 0008-5472
  • [AD] BUELOW VON G-U ET AL: "NF-AT ACTIVATION INDUCED BY A CAML-INTERACTING MEMBER OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 278, no. 5335, 3 October 1997 (1997-10-03), pages 138 - 141, XP002072292, ISSN: 0036-8075
  • [A] SMITH C A ET AL: "THE TNF RECEPTOR SUPERFAMILY OF CELLULAR AND VIRAL PROTEINS: ACTIVATION, COSTIMULATION, AND DEATH", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 76, 25 March 1994 (1994-03-25), pages 959 - 962, XP002029050, ISSN: 0092-8674
  • [A] ARMITAGE R J: "TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBERS AND THEIR LIGANDS", CURRENT OPINION IN IMMUNOLOGY, CURRENT BIOLOGY LTD, XX, vol. 6, no. 3, 1994, pages 407 - 413, XP000917867, ISSN: 0952-7915
  • [A] GRUSS H-J AND DOWER S K: "Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 85, no. 12, 15 June 1995 (1995-06-15), pages 3378 - 3404, XP002094502, ISSN: 0006-4971 & DATABASE EMBL [online] 25 September 1998 (1998-09-25), HAHNE AT AL.: "Homo sapiens proliferation inducing ligand APRIL mRNA, complete cds", XP002285266, retrieved from EMBL Database accession no. AF046888 & DATABASE GENEBANK [online] 19 September 2000 (2000-09-19), KELLY ET AL: "Tumor necrosis factor-related death ligand-1alpha [Homo sapiens]", XP002285267, retrieved from GENEBANK Database accession no. AAF59828 & DATABASE GENEBANK [online] 19 September 2000 (2000-09-19), KELLY ET AL: "Tumor necrosis factor-related death ligand-1beta [Homo sapiens]", XP002285268, retrieved from GENEBANK Database accession no. AAF59829
  • See references of WO 0196528A2

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

DOCDB simple family (publication)

WO 0196528 A2 20011220; WO 0196528 A3 20020808; AU 8285601 A 20011224; CA 2413160 A1 20011220; EP 1294949 A2 20030326; EP 1294949 A4 20040825; EP 2431054 A2 20120321; EP 2431054 A3 20130306

DOCDB simple family (application)

US 0119026 W 20010614; AU 8285601 A 20010614; CA 2413160 A 20010614; EP 01961605 A 20010614; EP 10011219 A 20010614