EP 1296954 A1 20030402 - BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA
Title (en)
BICYCLIC LACTAMS AND SULFONAMIDES WITH 5-HT1A-AFFINITY AND USE THEREOF FOR PREVENTING AND TREATING CEREBRAL ISCHAEMIA
Title (de)
BICYCLISCHE LACTAME UND SULFONAMIDE MIT 5-HT1A-AFFINITÄT UND IHRE VERWENDUNG ZUR PROPHYLAXE UND THERAPIE DER ZEREBRALEN ISCHÄMIE
Title (fr)
LACTAMES BICYCLIQUES ET SULFONAMIDES A AFFINITE 5-HT1A ET LEUR UTILISATION POUR LA PROPHYLAXIE ET LE TRAITEMENT DE L'ISCHEMIE CEREBRALE
Publication
Application
Priority
- DE 10031391 A 20000703
- EP 0107571 W 20010702
Abstract (en)
[origin: WO0202529A1] Compounds of formula (I), wherein the ring with the increment (N-A) can be 5, 6 or 7-membered and can also contain an oxygen or sulfur atom or a C-C double bond, with the exception of the 1,4-benzoxazepine skeleton, A represents a carbonyl or sulfonyl group, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, a carbon atom or CH and the bond between Y and Z can also be a double bond, n means the number 2, 3 or 4, R<1> can be a hydrogen atom, halogen or a C1-C4-alkyl, trifluoromethyl, hydroxy, C1-C4-alkoxy or amino group and R<2> represents a phenyl, pyridyl or pyrazinyl group which is optionally mono or di-substituted by C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which can be anellated with a benzole nucleus which can be mono or di-substituted by halogen atoms, C1-C4-alkyl, hydroxy, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and can optionally contain 1 nitrogen atom, or with a 5 or 6-membered ring which can contain 1 to 2 oxygen atoms; and physiologically compatible salts of these compounds show affinity for the 5-HT1A receptor and are suitable for treating cerebral ischaemia.
IPC 1-7
C07D 217/24; A61K 31/496; A61P 9/10; C07D 417/12; C07D 401/12; C07D 209/34; C07D 275/06; C07D 417/06; C07D 413/12; A61K 31/538; A61K 31/5415; A61K 31/553; A61K 31/554
IPC 8 full level
A61K 31/496 (2006.01); A61K 31/506 (2006.01); A61K 31/538 (2006.01); A61K 31/5415 (2006.01); A61K 31/55 (2006.01); A61K 31/553 (2006.01); A61K 31/554 (2006.01); A61P 9/00 (2006.01); A61P 9/10 (2006.01); A61P 17/02 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 209/32 (2006.01); C07D 209/34 (2006.01); C07D 217/24 (2006.01); C07D 275/06 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 417/06 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP US)
A61P 9/00 (2017.12 - EP); A61P 9/10 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07D 209/34 (2013.01 - EP US); C07D 217/24 (2013.01 - EP US); C07D 275/06 (2013.01 - EP US); C07D 401/12 (2013.01 - EP US); C07D 413/12 (2013.01 - EP US); C07D 417/06 (2013.01 - EP US); C07D 417/12 (2013.01 - EP US)
Citation (search report)
See references of WO 0202529A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0202529 A1 20020110; AR 028777 A1 20030521; AU 7637501 A 20020114; CA 2414726 A1 20030102; DE 10031391 A1 20020207; EP 1296954 A1 20030402; JP 2004502676 A 20040129; MX PA03000057 A 20040402; US 2004138203 A1 20040715
DOCDB simple family (application)
EP 0107571 W 20010702; AR P010103155 A 20010702; AU 7637501 A 20010702; CA 2414726 A 20010702; DE 10031391 A 20000703; EP 01954000 A 20010702; JP 2002507786 A 20010702; MX PA03000057 A 20010702; US 31281303 A 20031215