EP 1297003 A2 20030402 - A RECOMBINANT CELL LINE EXPRESSING GPCRx11 AS A FUNCTIONAL RECEPTOR VALIDATED BY ANGIOPEPTIN AND USEFUL FOR SCREENING OF AGONISTS AND ANTAGONISTS
Title (en)
A RECOMBINANT CELL LINE EXPRESSING GPCRx11 AS A FUNCTIONAL RECEPTOR VALIDATED BY ANGIOPEPTIN AND USEFUL FOR SCREENING OF AGONISTS AND ANTAGONISTS
Title (de)
EINE REKOMBINANTE ZELLLINIE, DIE GPCRX11 EXPRIMIEREN UND DIE EINEN FUNKTIONELLEN REZEPTOR FÜR ANGIOPEPTIN DARSTELLT UND SICH FÜR DAS SCREENING VON AGONISTEN UND ANTAGONISTEN EIGNET
Title (fr)
LIGNEE CELLULAIRE RECOMBINEE EXPRIMANT GPCRX11 EN TANT QUE RECEPTEUR FONCTIONNEL VALIDE PAR L'ANGIOPEPTINE ET UTILE DANS LE CRIBLAGE D'AGONISTES ET ANTAGONISTES
Publication
Application
Priority
- EP 01942923 A 20010620
- BE 0100104 W 20010620
- EP 01870015 A 20010126
- EP 01870024 A 20010212
- US 21291300 P 20000620
- US 21749400 P 20000711
Abstract (en)
[origin: WO0198330A2] The present invention is related to a G-protein coupled receptor or GPCRx11 similar to rat RTA receptor (37 %) and expressed in testis, thymus and uterus. Aequorin cell line expressing GPCRx11 has been used for screening of tissue extracts and reference ligands. GPCRx11 cells gave a specific signal with synthetic angiopeptin and a somatostatin analog allowing to validate this cell line for screening of natural or synthetic agonists and antagonists. In parallel, extended tissue distribution and polyclonal antibodies have been produced to facilitate GPCRx11 characterisation.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); A61K 45/00 (2006.01); A61P 1/04 (2006.01); A61P 1/08 (2006.01); A61P 1/14 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61P 7/10 (2006.01); A61P 9/00 (2006.01); A61P 9/02 (2006.01); A61P 9/04 (2006.01); A61P 9/10 (2006.01); A61P 9/12 (2006.01); A61P 9/14 (2006.01); A61P 13/08 (2006.01); A61P 17/02 (2006.01); A61P 19/08 (2006.01); A61P 19/10 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/04 (2006.01); A61P 31/10 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 35/04 (2006.01); A61P 37/02 (2006.01); A61P 37/08 (2006.01); A61P 43/00 (2006.01); C07K 14/00 (2006.01); C07K 14/705 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/02 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 1/04 (2017.12); A61P 1/08 (2017.12); A61P 1/14 (2017.12); A61P 3/04 (2017.12); A61P 3/10 (2017.12); A61P 7/10 (2017.12); A61P 9/00 (2017.12); A61P 9/02 (2017.12); A61P 9/04 (2017.12); A61P 9/10 (2017.12); A61P 9/12 (2017.12); A61P 9/14 (2017.12); A61P 13/08 (2017.12); A61P 17/02 (2017.12); A61P 19/08 (2017.12); A61P 19/10 (2017.12); A61P 25/04 (2017.12); A61P 25/06 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/18 (2017.12); A61P 25/22 (2017.12); A61P 25/24 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 31/04 (2017.12); A61P 31/10 (2017.12); A61P 31/12 (2017.12); A61P 35/00 (2017.12); A61P 35/04 (2017.12); A61P 37/02 (2017.12); A61P 37/08 (2017.12); A61P 43/00 (2017.12); C07K 14/705 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01)
Citation (search report)
See references of WO 0198330A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
DOCDB simple family (publication)
WO 0198330 A2 20011227; WO 0198330 A3 20020502; AU 6571701 A 20020102; CA 2413435 A1 20011227; EP 1297003 A2 20030402; JP 2004500125 A 20040108
DOCDB simple family (application)
BE 0100104 W 20010620; AU 6571701 A 20010620; CA 2413435 A 20010620; EP 01942923 A 20010620; JP 2002504285 A 20010620